Home >
Medicine Info >
Avonza Tablet
Loading interface...

Avonza Tablet

Manufactured byMylan Pharmaceuticals
ContainsTenofovir (300 mg) + Lamivudine (300 mg) + Efavirenz (400 mg)
Description
Avonza Tablet is a combination of Tenofovir, Lamivudine, and Efavirenz. It is an antiviral medicine used for the treatment of human immunodeficiency virus (HIV) infection (a condition that occurs when the virus attacks the immune system and interferes with your body's ability to fight infections or diseases). Avonza Tablet will not cure HIV infection, but it will delay the progression of a chronic, potentially life-threatening condition known as acquired immunodeficiency syndrome (AIDS) and other HIV-related conditions. This medicine works by preventing the virus from multiplying. Avonza Tablet shows some side effects like nausea, vomiting, stomach pain, diarrhoea, headache, confusion, dizziness, trouble sleeping, etc. Consult your doctor if they bother you for a longer time or worsen. Do not take this medicine if you are allergic to it. Avonza Tablet should be taken on an empty stomach, or one hour before or two hours after a meal. Take it preferably at bedtime to make some of the side effects less bothersome. Take it in the dose and duration prescribed by your doctor. Do not take more than the recommended dose. Take it every day at the same time to maintain a consistent level of this medicine in your blood. Take this medicine for the recommended duration. Do not discontinue this medication without consulting your doctor, as it may worsen your condition. Avonza Tablet may not be suitable for everyone. It is not recommended for use in children weighing less than 40 kg. Inform your doctor if you have heart, liver, or kidney problems or any other health conditions to make sure it is safe for you. Also, inform your doctor about all your ongoing medications to avoid undesired effects. Avonza Tablet is unsafe for use during pregnancy. If you have an HIV infection, it is not recommended to breastfeed, as the Human immunodeficiency virus (HIV) may transfer to the baby through breastmilk.
QUICK LINKS:
Side effectsConcernsUsage

Side effects

Major & minor side effects for Avonza Tablet

  • Diarrhoea
  • Headache
  • Fatigue
  • Loss of appetite
  • Depression
  • Stuffy nose
  • Muscle pain
  • Heartburn
  • Indigestion
  • Sore throat
  • Cough
  • Chest pain
  • Rash
  • Trouble sleeping
  • Drowsiness
  • Forgetfulness
  • Confusion
  • Nausea or Vomiting

Uses of Avonza Tablet

What is it prescribed for?

  • HIV infection
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Avonza Tablet to show its effect is not clinically established.
  • How long do the effects of this medicine last?
    The time duration for which Avonza Tablet remains active in your body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported Avonza Tablet.
  • Can this medicine be taken during pregnancy?
    Avonza Tablet is unsafe for use during pregnancy as it can harm your developing foetus. Hence, consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Avonza Tablet is not recommended for use while breastfeeding. Also, women with HIV infection is not recommended to breastfeed as the Human immunodeficiency virus (HIV) can be passed to the baby through breastmilk.

Allergy

Avoid taking Avonza Tablet if you are allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Moderate to severe liver impairment

Avonza Tablet is not recommended for use if you have moderate to severe liver problems, as this medicine may cause liver toxicity and further worsen your condition.

Elbasvir/Grazoprevir

Elbasvir/Grazoprevir are antiviral medicines used in the treatment of hepatitis C (a viral infection that causes swelling of the liver). Avonza Tablet may decrease the blood concentration of Elbasvir/Grazoprevir, resulting in the loss of its therapeutic effect. Hence, the combined use of Avonza Tablet and Elbasvir/Grazoprevir is not recommended.
Warnings for special population

Pregnancy

Avonza Tablet is unsafe for use during pregnancy as it can harm your developing foetus. Hence, consult your doctor if you are pregnant.

Breast-feeding

Avonza Tablet is not recommended for use while breastfeeding. Also, women with HIV infection is not recommended to breastfeed as the Human immunodeficiency virus (HIV) can be passed to the baby through breastmilk.
General warnings

Immune reconstitution syndrome

Changes in your immune system can occur when you start taking Avonza Tablet. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. It may cause an exaggerated response making the symptoms of infection worse. Inform your doctor if you develop any new symptoms after starting treatment with Avonza Tablet.

Lactic acidosis

Lactic acidosis is a build-up of lactic acid in the bloodstream. Avonza Tablet should be used with caution due to the increased risk of lactic acidosis. Report any unusual symptoms like muscle cramps, unusual weakness or tiredness, feeling dizzy or lightheaded, fast or abnormal heartbeat, etc., to your doctor immediately.

Decreased bone mineral density

Avonza Tablet should be used with caution as it may cause a decrease in bone mineral density (amount of bone mineral in your bones).

Fat redistribution

Avonza Tablet should be used with caution as it may cause fat gain or fat loss in the body. It may result in central obesity, buffalo hump (excess fat behind the neck), peripheral wasting (difficulty in moving an arm or leg or making any movement), facial wasting (fat loss in the cheeks and temples), breast enlargement, and cushingoid appearance (extra fat build up on the sides of the face and weight gain). Consult your doctor if you have any concerns.

Use in children

Avonza Tablet is not recommended for use in children with body weight less than 40 kg.

Driving or operating machines

Avonza Tablet may cause dizziness, drowsiness, and impaired concentration. Hence, avoid performing activities that require mental alertness such as driving vehicles or operating machines if you experience such symptoms.

Missed Dose

Take the missed dose of Avonza Tablet as soon as you remember. Skip the missed dose if it is time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Never take more than the prescribed dose of Avonza Tablet. Seek emergency medical treatment in case of an overdose for further guidance.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Citalopram

Fluconazole

Amiodarone

Ciprofloxacin

Azithromycin

Disease interactions

Increase in cholesterol levels

Avonza Tablet should be used with caution as it may cause an increase in cholesterol and fats level in the blood. Your doctor may suggest tests to periodically monitor your lipid (fats) levels in the blood while you are taking this medicine.

CNS disorders

Use of Avonza Tablet may cause depression, aggressive behaviour, confusion, suicidal thoughts, etc. Hence this medicine should be used with extreme caution if you have a history of mental problems due to the increased risk of worsening your condition. Inform your doctor immediately if you experience any change in mood and behaviour or develop thoughts of self-harm.

Kidney Disease

Avonza Tablet should be used with caution if you have kidney problems as this medicine is filtered by the kidney. If you have impaired kidney function, it may cause an accumulation of this medicine in your body and increase the risk of undesired effects. Your doctor may adjust the dose based on your clinical condition.

QT Prolongation

QT prolongation is a condition in which your heart muscles take a longer time to recharge between a heartbeat. Avonza Tablet should be used with caution as it may cause QT prolongation. It is not recommended for use if you have any clinical condition or taking any medication known to cause QT prolongation.

Seizures

Seizure is a condition that occurs due to disturbed nerve cell activity in your brain resulting in abnormal behaviour and loss of consciousness. Avonza Tablet should be used with caution if you have a history of seizures as this medicine may trigger seizures.

Pancreatitis

Pancreatitis refers to the swelling of the pancreas, a gland that produces chemical substances which help in digestion and regulation of blood sugar. Avonza Tablet should be used with caution as it may cause pancreatitis. The risk is especially higher if you have a history of pancreatitis.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Avonza Tablet exactly as instructed by your doctor. Do not take in larger or smaller quantities than recommended. Avoid the discontinuation of this medicine without consulting your doctor, as it can worsen your condition. Inform your doctor immediately if you experience any change in mood or behaviour or develop suicidal thoughts. Your doctor may suggest tests to monitor your liver function and lipid (fats) levels during treatment with this medicine. Avoid driving vehicles or operating machines, as this medicine can make you feel dizzy or drowsy. This medicine may cause redistribution and accumulation of body fat in different parts of your body, such as below your neck, upper back, breasts, or around the stomach. It may also cause loss of body fat from your legs, arms, and face. Consult your doctor if you have any concerns.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
Avonza Tablet works by stopping the human immunodeficiency virus (HIV) from multiplying.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Antiviral combinations

Schedule

Schedule H

Drugs, H., 2021. Efavirenz: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 23 November 2021].

https://medlineplus.gov/druginfo/meds/a699004.html>

Medicines.org.uk. 2022. Efavirenz Mylan 600 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 18 February 2022].

https://www.medicines.org.uk/emc/product/719/smpc>

Accessdata.fda.gov. 2022. [online] Available at: < [Accessed 18 February 2022].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022142s037lbl.pdf>

Drugs, H., 2022. Tenofovir: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 28 February 2022].

https://medlineplus.gov/druginfo/meds/a602018.html>
Loading related questions...
Something doesn’t feel right?
Report an error

Information on this page was last updated on 15 Jul 2022

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.