Atezolizumab

Description

Atezolizumab is an anticancer medicine used alone or in combination with other medicines for the treatment of various types of cancers such as non-small-cell lung cancer (NSCLC), small cell lung cancer (SCLC), Urothelial cancer (a type of cancer lining of the bladder and urinary tract cancer), and breast cancer. This medicine is not recommended for use in patients below 18 years of age.

Side effects

Major & minor side effects for Atezolizumab

  • Bladder pain
  • Bloating
  • Chills
  • Bloody and Cloudy urine
  • Constipation
  • Rapid weight gain
  • Nausea and Vomiting
  • Drowsiness
  • Skin Rash
  • Hair loss
  • Headache
  • Irritability

Uses of Atezolizumab

What is it prescribed for?

  • Bladder cancer (Urothelial Carcinoma)
  • Non-Small Cell Lung Cancer
  • Triple- Negative Breast cancer
  • Small Cell Lung Cancer
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Atezolizumab, or any other inactive ingredients present in the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Pneumonitis

This medicine should be used with caution since it may increase the risk of immune-related pneumonitis. Report any unusual symptoms to the doctor on priority. Appropriate corrective measures or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Regular monitoring of kidney function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Colitis

This medicine should be used with caution since it may increase the risk of immune-related colitis or diarrhea. Report any unusual symptoms to the doctor on priority. Appropriate corrective measures or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machinery

Use of this medicine may rarely cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during the treatment with this medicine.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Etanercept

Adalimumab

Baricitinib

Tofacitinib

Certolizumab

Fingolimod

Golimumab

Disease interactions

Endocrinopathy

This medicine should be used with caution in patients with endocrinopathy (disease-related with endocrine gland) due to the increased risk of worsening of the patient's condition. Close monitoring for the signs and symptoms is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative might be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Close monitoring of the liver function, appropriate dose adjustments, or replacement with a suitable alternative might be required in some cases based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Close monitoring of the kidney function, appropriate dose adjustments, or replacement with a suitable alternative might be required in some cases based on the clinical condition.

meningitis

This medicine should be used with caution since it may increase the risk of immune-related meningoencephalitis. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative should be considered under your doctor's supervision.

Infections

This medicine should be used with extreme caution in patients with severe infections due to the increased risk of retroperitoneal hemorrhage. Initiation of therapy with this medicine in patients with active infections is not recommended. Patients susceptible to infections should be monitored closely during treatment with this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines including any herbs and supplements as well as your medical conditions before receiving this medicine. Consult your doctor immediately if you develop any signs and symptoms of an infection.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by enhancing your immune system against the growth of cancer cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Anti-PD-1 monoclonal antibodies

Schedule

Schedule H

Tecentriq 1,200 mg concentrate for solution for infusion - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 27 March 2019]. Available from:

https://www.medicines.org.uk/emc/product/8442/smpc

[Internet]. Accessdata.fda.gov. 2019 [cited 27 March 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/761034s010lbl.pdf

Atezolizumab - DrugBank [Internet]. Drugbank.ca. 2019 [cited 27 March 2019]. Available from:

https://www.drugbank.ca/drugs/DB11595

DailyMed - TECENTRIQ- atezolizumab injection, solution [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 27 March 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6fa682c9-a312-4932-9831-f286908660ee

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Information on this page was last updated on 16 Aug 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.