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Asomex-OH Tablet

Manufactured byEMCURE PHARMACEUTICALS LTD
ContainsHydrochlorothiazide (12.5 mg) + S-Amlodipine (2.5 mg) + Olmesartan (20 mg)
Description

Asomex-OH Tablet is a combination medicine used for the treatment of high blood pressure. This medicine is not recommended for use in patients below 18 years of age. It is also not recommended as initial therapy for high blood pressure. Patients are advised to maintain a strict exercise and diet regimen along with this medicine for the best possible effect.

Side effects

Major & minor side effects for Asomex-OH Tablet

  • Body pain
  • Headache
  • Chills
  • Nasal congestion
  • Unusual tiredness and weakness
  • Blood in urine
  • Joint pain
  • Swelling of feet or lower legs
  • Bladder pain
  • Diarrhea
  • Dry mouth
  • Increased urination
  • Acid or sour stomach
  • Skin rash
  • Heartburn
  • Dizziness

Uses of Asomex-OH Tablet

What is it prescribed for?

  • Essential hypertension
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 2 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to hydrochlorothiazide, other sulfonamides, S-amlodipine, other calcium-channel blockers, olmesartan, other angiotensin receptor blockers, or any other inactive ingredients present along with the formulation.

Aliskiren

Coadministration of aliskiren and this combination medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.

Anuria

This medicine is not recommended for use in patients with anuria (a condition where the kidney is unable to produce urine) due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe kidney impairment due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hypotension

Use of this medicine may increase the risk of hypotension, especially in patients with volume depletion. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hyperkalemia

This medicine may increase potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (potassium-sparing diuretics and potassium supplements) during treatment with this medicine.

Use in children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Coronary artery diseases

This medicine should be used with extreme caution in patients suffering from coronary artery diseases since it may worsen the patient's condition. Close monitoring of heart function and vital signs is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver impairment

This medicine should be used with caution in patients with liver impairment. Close monitoring of liver function is necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Volume and electrolyte depletion

This medicine may alter the blood volume and electrolyte levels in some patients. This may cause dizziness, dry mouth, and acid-base imbalance. This risk is especially higher in patients suffering from kidney and liver diseases. Close monitoring of blood pressure and electrolyte levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney diseases

This medicine should be used with extreme caution in patients with kidney impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Driving and operating machines

This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Eye diseases

This medicine should be used with extreme caution in patients with eye diseases such as acute myopia or secondary angle-closure glaucoma due to the increased risk of worsening of the patient's condition. Close monitoring of eye function is recommended for such patients. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Carbamazepine

Dexamethasone

Itraconazole

Rifampicin

Aliskiren

Captopril

Insulin

Antidepressants

Nonsteroidal anti-inflammatory medicines

Disease interactions

Congestive heart failure

This medicine should be used with caution in patients with congestive heart failure due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Cardiogenic shock

This medicine is not recommended for use in patients suffering from a cardiogenic shock since it may worsen the patient's condition.

Diabetes

This medicine should be used with caution in patients with diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia since this medicine decreases the uric acid excretion and this may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Coronary Artery Disease

This medicine should be used with extreme caution in patients with coronary artery diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects such as dizziness, headache, swelling of hands and feet, etc.
It is recommended to avoid a high potassium diet during treatment with this medicine due to the increased risk of serious adverse effects. Your doctor/dietitian will suggest an appropriate diet for you to avoid high intake of potassium.
Lab interactions
Information not available.
Take this medicine exactly as advised by your doctor. It can be taken with or without food. Do not take in larger amounts than advised or prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Hydrochlorothiazide increases the excretion of water and sodium through the urine. S-amlodipine relaxes the heart muscles and the blood vessels. Olmesartan relaxes the blood vessels and promotes a smooth flow of blood. Their combination is thus effective in lowering the blood pressure.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Miscellaneous antihypertensive combinations

Schedule

Schedule H

Hydrochlorothiazide - DrugBank [Internet]. Drugbank.ca. 2017 [cited 21 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB00999

Olmesartan: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 8 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a603006.html

Amlodipine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 7 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a692044.html

DailyMed - Amlodipine tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 7 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1cec7a02-b7a5-49e1-ab64-3a4dab4149d2
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Information on this page was last updated on 14 Jun 2019

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