Arilex 50 mg Capsule

Manufactured byAlembic Ltd.
ContainsDiacerein
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Description

Arilex 50 mg Capsule is a medicine that belongs to the anthraquinone class and is used to treat the symptoms associated with degenerative diseases of the bones and joints. It is used to relieve pain and swelling associated with Osteoarthritis. This medicine is slow acting and is used as a long-term treatment option for osteoarthritis.

Side effects

Major & minor side effects for Arilex 50 mg Capsule

  • Diarrhea
  • Stomach discomfort and pain
  • Nausea
  • Vomiting
  • Yellowing of skin and eyes
  • Intense yellow urine
  • Increase in liver enzyme levels
  • Allergic skin reaction

Uses of Arilex 50 mg Capsule

What is it prescribed for?

  • Osteoarthritis
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Concerns

Commonly asked questions

  • Onset of action
    This medicine is slow acting and takes around 4-8 weeks to show its effect.
  • Duration of effect
    The effect of this medicine is cumulative and can be observed for 4-8 weeks after the treatment is stopped.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnancy. Consult your doctor and discuss the risks and benefits before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women as the risk of adverse effects on the nursing infant is significantly high. Your doctor will determine the best course of treatment based on your clinical condition.

Allergy

This medicine is not recommended for use if you have a known allergy to Arilex 50 mg Capsule or any other medicine belonging to the anthraquinone class.

Severe kidney damage

This medicine is not recommended for use in patients having a severe impairment of kidney function.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnancy. Consult your doctor and discuss the risks and benefits before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women as the risk of adverse effects on the nursing infant is significantly high. Your doctor will determine the best course of treatment based on your clinical condition.
General warnings

Diarrhea

Use of this medicine may cause diarrhea or loose stools in the first few days of treatment. Contact your doctor if the complication is not resolved within 3-4 days.

Antibiotic therapy

This medicine should not be taken with antibiotics as the risk of gastric irritation and persistent diarrhea is significantly high in such cases. Your doctor may make appropriate changes to your therapy based on your clinical condition.

Kidney disease

This medicine should be used with caution in patients having an impairment of kidney function. Appropriate dose adjustments and regular monitoring of kidney functions are recommended while using this medicine.

Diagnostic tests

It is recommended to monitor liver function, kidney function, complete blood count, and urine tests every six months while taking this medicine.

Intense yellowing of urine

Use of this medicine may cause intense yellow coloration of the urine. This is mainly due to the excretion of end products and may not be indicative of any complication.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for the next scheduled dose, then the missed dose can be skipped. Contact your doctor if you miss more than one scheduled dose.

Overdose

Contact your doctor if an overdose with this medicine is suspected. Symptoms of an overdose may include severe stomach discomfort and diarrhea.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Aluminium Hydroxide/Magnesium Hydroxide

Amoxycillin

Laxatives

Disease interactions

Irritable bowel syndrome

This medicine should be used with caution in patients having an irritable bowel or other associated conditions of the gastrointestinal tract due to an increase in the risk of adverse effects.

Kidney Disease

This medicine is not recommended for use in patients having a severe impairment of the normal kidney function. Appropriate diagnostic tests must be performed to rule out any kidney disease before treatment with Arilex 50 mg Capsule is initiated.
Food interactions
A diet rich in dietary fibers and phytates may interfere with the absorption of this medicine. Hence, administration of Arilex 50 mg Capsule with a diet rich in fibers and phytates should be avoided. Your doctor/dietitian may suggest appropriate changes in your diet based on your clinical condition.
Lab interactions
Information not available.
Take Arilex 50 mg Capsule exactly as instructed by the doctor. Contact your doctor if you experience prolonged diarrhea in the initial phase of treatment. Your doctor may also begin the treatment with a lower dose to minimize the side effects. Do not take this medicine in smaller or larger quantities than recommended.
Miscelleneous

To be taken immediately after food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by blocking the actions of a certain specific protein that causes swelling, pain, and degradation of cartilage at bone joints.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Nonsteroidal anti-inflammatory agents, Antirheumatics

Schedule

Schedule H

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http://highnoon-labs.com/wp-content/uploads/2015/04/Artrodar-Insert.pdf

Diacerein - DrugBank [Internet]. Drugbank.ca. 2017 [cited 13 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB11994

Diacerein | C19H12O8 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 13 July 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/26248#section=Top

diacerein: Indication, Dosage, Side Effect, Precaution | CIMS India [Internet]. Mims.com. 2017 [cited 13 July 2017]. Available from:

http://www.mims.com/india/drug/info/diacerein?type=full&mtype=generic

EMA Panel Says Diacerein Should Stay, but With Restrictions [Internet]. Medscape. 2017 [cited 13 July 2017]. Available from:

http://www.medscape.com/viewarticle/821654

Fidelix T, Macedo C, Maxwell L, Fernandes Moça Trevisani V. Diacerein for osteoarthritis [Internet]. 2017 [cited 13 July 2017]. Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005117.pub3/full

http://onlinelibrary.wiley.com/cochranelibrary/search/.

Pelletier JP e. Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 13 July 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/11037895
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