Aprotinin

Description

Aprotinin is used to reduce blood loss during and after complex surgeries such as heart and liver surgery in adult patients. It helps to reduce the necessity for a blood transfusion during and after surgeries.

Side effects

Major & minor side effects for Aprotinin

  • Fever or chills
  • Constipation or diarrhea
  • Difficulty in breathing
  • Decreased blood pressure
  • Weakness
  • Skin rash, hives, or itching
  • Chest pain
  • Difficulty in urinating
  • Irregular heart beat
  • Stomach pain
  • Headache
  • Dizziness and fainting
  • Nausea and Vomiting

Uses of Aprotinin

What is it prescribed for?

  • Prophylactic use to reduce blood loss
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed immediately on an intravenous administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients who have a known history of allergy to aprotinin or any other inactive ingredients present along with it.

Aprotinin-specific IgG antibody test

This medicine is not recommended for use in patients with a positive aprotinin-specific IgG antibody test due to the risk of anaphylactic reaction. If no aprotinin specific IgG antibody test is performed prior to the therapy, and if the patient has a known or suspected previous exposure to Aprotinin, including aprotinin-containing medicinal products within the last 12 months, use of this medicine is not recommended.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Test dose

Use a test dose of Aprotinin in patients prior to the therapy to determine the possibility of anaphylactic reactions.

Cardiac disorders

This medicine should be used with extreme caution in patients with heart disorders such as heart failure, heart attacks, etc. due to the risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Kidney impairment

This medicine should be used with extreme caution in patients with kidney impairment due to the risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Other uses

Your doctor may use this medicine for indications other than those stated above in certain specific circumstances, especially if other medicines are not effective. All the risks and benefits should be discussed with the doctor in such cases.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Since this medicine is mostly given before and during a surgical procedure, the likelihood of missing a dose is very less.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Captopril

Tretinoin

Thrombolytic agents

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Effect on sleep is not established

How it works
Aprotinin works by inhibiting the action of certain chemicals that are responsible for the breakdown of blood clots.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antifibrinolytic agents

Schedule

Schedule H

[Internet]. Drugbank.ca. 2018 [cited 31 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB06692

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 31 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/53487898#section=Wikipedia

[Internet]. Docetp.mpa.se. 2018 [cited 31 December 2018]. Available from:

https://docetp.mpa.se/LMF/Trasylol%20solution%20for%20injection%20or%20infusion%20PL_09001be681f74695.pdf

[Internet]. Ec.europa.eu. 2018 [cited 31 December 2018]. Available from:

https://ec.europa.eu/health/documents/community-register/2013/20130918126790/anx_126790_en.pdf

Aprotinin 10,000 KIU/ml Injection BP - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 20 February 2019]. Available from:

https://www.medicines.org.uk/emc/product/2472/smpc

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Information on this page was last updated on 20 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.