Apremilast

Description

Apremilast is an anti-rheumatic agent used for the treatment of active psoriatic arthritis, a form of arthritis associated with psoriasis. It is also used for the treatment of moderate-to-severe plaque psoriasis, a severe skin condition characterized by symptoms such as skin rashes, scales on the skin, etc. This medicine is not recommended for use in patients less than 18 years of age.

Side effects

Major & minor side effects for Apremilast

  • Diarrhea
  • Nausea and Vomiting
  • Headache
  • Upper respiratory tract infection
  • Abdominal pain
  • Runny nose and sore throat
  • Loss of appetite
  • Suicidal thinking and behaviour
  • Sleep disturbances
  • Unusual tiredness and weakness

Uses of Apremilast

What is it prescribed for?

  • Psoriatic Arthritis
  • Plaque Psoriasis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its effect is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains effective in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any undesirable side effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to apremilast or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any undesirable side effects.
General warnings

Depression

This medicine should be used with caution due to the increased risk of depressive symptoms, mood changes, changes in behavior, etc. Patients should be monitored closely for any changes in mood and behavior during treatment with this medicine. Appropriate patient and caregiver counseling, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Severe diarrhea

This medicine should be used with caution due to the increased risk of severe diarrhea, nausea, and vomiting. Following all steps of dose titration is necessary to reduce the risk of these side effects. Report any such symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Weight loss

This medicine should be used with caution due to the increased risk of weight loss. This risk is especially higher in patients with a history of anorexia and/or malnourishment. Close monitoring of weight changes is recommended during treatment with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor if you suspect an overdose of this medicine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Dexamethasone

Phenobarbital

Bosentan

Griseofulvin

Fosphenytoin

Efavirenz

Carbamazepine

Rifampicin

Primidone

Disease interactions

Depression

This medicine should be used with caution in patients with a history of depression /suicidal thoughts and behavior due to the increased risk of worsening of the patient's condition. Close monitoring of changes in mood and behavior is recommended for such patients. Appropriate patient/caregiver counseling, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Impaired kidney function

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Anorexia

This medicine should be used with caution in patients suffering from anorexia or malnutrition due to the increased risk of further weight loss. Close monitoring of weight changes is recommended for these patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than advised. The dose strength is likely to change during the course of treatment, follow all the instructions given by your doctor. Report any undesirable side effects to the doctor immediately. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by blocking the action of certain natural substances in the body that are responsible for causing swelling, redness, and scales on the skin.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antirheumatics

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 1 August 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205437s000lbl.pdf

[Internet]. Media.celgene.com. 2018 [cited 1 August 2018]. Available from:

http://media.celgene.com/content/uploads/otezla-pi.pdf

[Internet]. Bad.org.uk. 2018 [cited 1 August 2018]. Available from:

http://www.bad.org.uk/shared/get-file.ashx?id=5904&itemtype=document

Apremilast - DrugBank [Internet]. Drugbank.ca. 2018 [cited 1 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB05676

DailyMed - Apremilast tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 1 August 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3acf6751-827d-11e2-9e96-0800200c9a66

Otezla® (apremilast) Official Site | Psoriasis Medication [Internet]. Otezla.com. 2018 [cited 1 August 2018]. Available from:

https://www.otezla.com/

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Information on this page was last updated on 2 Aug 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.