Apixaban

Description

Apixaban is an anticoagulant that is used to prevent blood clots. The patient should inform about any active bleeding disorder or a history of bleeding disorder to the doctor before taking this medicine. Close monitoring of liver and kidney function is necessary while receiving the medicine.

Side effects

Major & minor side effects for Apixaban

  • Anemia
  • Constipation
  • Dizziness
  • Nose bleed
  • Skin rash
  • Stomach pain
  • Headache
  • Redness of the eye
  • Nausea and Vomiting
  • Swelling of face, lips, eyelids, and tongue

Uses of Apixaban

What is it prescribed for?

  • Prophylaxis for Deep Vein Thrombosis
  • Thromboembolic Stroke Prophylaxis
  • Pulmonary Embolism
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Concerns

Commonly asked questions

  • Onset of action
    The peak levels of this medicine can be observed in 3 to 4 hours after an oral dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 24 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Apixaban.

Bleeding disorder

This medicine is not recommended for use in patients with a bleeding disorder.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Bleeding

This medicine is known to increase the risk of bleeding in patients with bleeding disorders, gastrointestinal bleeding, uncontrolled hypertension, and some eye disorders.

Impaired kidney function

This medicine may increase the risk of bleeding in patients with severely impaired kidney function. Dose adjustments are to be made based on the CrCl.

Impaired liver function

This medicine is known to increase the liver enzymes and therefore, it should be used with caution in patients with impaired liver function. It is recommended to avoid using this medicine in patients with moderate to severe liver function impairment.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost the time for the next scheduled dose, then the missed dose should be skipped.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clarithromycin

Escitalopram

Nonsteroidal anti-inflammatory drugs

Ciprofloxacin

Disease interactions

Bleeding disorders

This medicine may increase the risk of bleeding in patients with a genetic bleeding disorder called haemophilia or any unusual bleeding in the gastrointestinal tract. An alternate medicine should be considered based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Apixaban as prescribed by the doctor. Do not take this medicine in larger or smaller quantities than recommended. The treatment should be started at lower doses and the dose should be gradually increased based on the response. Do not stop taking this medicine without informing your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by inhibiting the clotting factors that cause the blood to clot.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Factor Xa inhibitors

Schedule

Schedule H

[Internet]. 2017 [cited 4 July 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/24988

DailyMed - apixaban tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 4 July 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e9481622-7cc6-418a-acb6-c5450daae9b0

Apixaban: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 4 July 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a613032.html

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 4 July 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database

Toxnet.nlm.nih.gov. 2017 [cited 4 July 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2

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Information on this page was last updated on 5 Jan 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.