Anzavir-R Tablet

Manufactured byMylan Pharmaceuticals
ContainsAtazanavir (300 mg) + Ritonavir (100 mg)
Description

Anzavir-R Tablet is a combination medicine used in the treatment of human immunodeficiency virus (HIV) infection. This medicine is not a cure for HIV. It only prevents the virus from multiplying in your body. This medicine is not recommended for use in patients weighing less than 40 kgs.

Substitutes

List of substitutes for Anzavir-R Tablet

Side effects

Major & minor side effects for Anzavir-R Tablet

  • Feeling of warmth or heat
  • Redness of the skin especially on the face and neck
  • Headache
  • Weight loss
  • Confusion
  • Acid or sour stomach
  • Change in sense of taste
  • Sleepiness or unusual drowsiness
  • Mood or mental changes
  • Tender, swollen glands in the neck
  • Skin Rash
  • Sweating
  • Stomach pain
  • Diarrhea
  • Dry mouth
  • Nausea and Vomiting
  • Runny Nose

Uses of Anzavir-R Tablet

What is it prescribed for?

  • HIV infection
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is recommended for use in breastfeeding women only in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to atazanavir, ritonavir, or any other inactive ingredients present along with these medicines.

Drug interaction

This medicine is not recommended for use in patients receiving medicines which are highly dependent on CYP3A or UGT1A1 for their clearance as well as strong CYP3A inducers due to an increased risk of alteration in the blood levels of this combination medicine, which may cause serious and life-threatening reactions.

Severe Hepatic impairment

This medicine is not recommended for use in patients with a known history of severe hepatic impairment due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is recommended for use in breastfeeding women only in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Hepatotoxicity

This medicine should be used with caution in patients with a history of liver diseases and active liver diseases due to the increased risk of hepatotoxicity. Report any unusual symptoms to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Bleeding disorders

This medicine should be used with caution in patients with bleeding disorders such as Hemophilia A or Hemophilia B due to an increase in the risk of excessive bleeding. Report any unusual symptoms to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Fat Redistribution

This medicine may cause fat gain or fat loss from the body. This may result in peripheral wasting, facial wasting, breast enlargement, and Cushingoid appearance. Close monitoring of body weight and body fat distribution is necessary while receiving this medicine. Any changes in the body should be informed to the doctor on priority.

Diabetes

This medicine may alter the blood glucose levels and may also increase the risk of new-onset diabetes mellitus. Close monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments of the anti-diabetic agents or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Pancreatitis

This medicine may cause pancreatitis in some patients. Report any unusual symptoms to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Immune reconstitution syndrome

This medicine should be used with caution due to an increase in the risk of immune reconstitution syndrome. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Nephrolithiasis

This medicine should be used with caution due to an increase in the risk of nephrolithiasis (kidney stones). Report any unusual symptoms to the doctor immediately. Close monitoring of kidney function or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Elevated bilirubin

This medicine should be used with caution due to an increase in the risk of elevated bilirubin levels. Close monitoring of bilirubin levels or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Carbamazepine

Cisapride

Erythromycin

Fluoxetine

Loperamide

Midazolam

Cyclosporine

Lovastatin

Alprazolam

Atorvastatin

Disease interactions

Liver Disease

This medicine should be used with extreme caution in patients with a known history of liver diseases due to the increased risk of worsening of the patient's condition. Liver function should be assessed before initiating the treatment. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Diabetes

This medicine should be used with caution due to an increase in the risk of elevated blood glucose levels. Blood glucose levels should be monitored closely during treatment with this medicine. Report any symptoms such as an increased frequency of urination, excessive thirst, etc. to the doctor on priority. If necessary, the dose of the antidiabetic agents should be adjusted based on the clinical condition.

Bleeding disorders

This medicine should be used with caution in patients with a known history of bleeding disorders due to the increased risk of excessive bleeding. Close monitoring of INR or prothrombin time is necessary for such patients. Replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart Disease

This medicine should be used with caution in patients with a history of heart disease and active heart diseases. Close monitoring of heart function is advised during treatment with this medicine. Replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller quantities than recommended. Ensure that proper hygiene measures are adopted. Complete the course of treatment to prevent the spread of the infection. Close monitoring of liver function and blood glucose levels is necessary while receiving this medicine.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by stopping the human immunodeficiency virus (HIV) from multiplying. This helps in reducing the chances of development of acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Protease inhibitors

Schedule

Schedule H

[Internet]. CiplaMed. 2018 [cited 8 March 2018]. Available from:

https://ciplamed.com/content/synthivan-tablets

[Internet]. Accessdata.fda.gov. 2018 [cited 8 March 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021567s039,206352s004lbl.pdf

Atazanavir: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 21 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a603019.html

Ritonavir: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 12 July 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a696029.html

[Internet]. 2017 [cited 12 July 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/22952#
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