Anti-thymocyte globulin (Rabbit Derived)

Description

Anti-thymocyte globulin (Rabbit Derived) is an immunosuppressive agent which helps to prevent the immune system from attacking transplanted organs especially in kidney transplanted patients. Thus this medicine helps to avoid organ rejections in patients receiving organ transplantation.

Side effects

Major & minor side effects for Anti-thymocyte globulin (Rabbit Derived)

  • Severe allergic reaction
  • Decrease in blood cell count
  • Nausea and vomiting
  • Diarrhea
  • Infections
  • Muscle pain
  • Confusion
  • Loss of appetite
  • Unusual tiredness or weakness
  • Headache

Uses of Anti-thymocyte globulin (Rabbit Derived)

What is it prescribed for?

  • Organ Transplant - Rejection Prophylaxis
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 24 hours of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary.

Allergy

This medicine is not recommended for use in patients with a known allergy to Anti-thymocyte globulin or any rabbit proteins or any other inactive ingredient present along with it.

Active infections

This medicine is not recommended for use in patients with active acute or chronic infections due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary.
General warnings

Under medical supervision

This medicine should strictly be administered under the supervision of a qualified healthcare professional with experience of immunosuppressive therapy in the transplant setting. Close monitoring of the patient is recommended during the infusion and until the end of the infusion.

Severe allergic reactions

Severe allergic reactions may occur with this medicine, specifically contraindicated in patients with a previous history of allergy to any rabbit proteins and/or immunoglobulins. Precautions for immediate treatment should be available during use. If symptoms of allergic reactions occur, discontinue immediately and initiate appropriate treatment.

Infections

Use of this medicine may affect the immune system making you susceptible to opportunistic infections from a wide variety of pathogens. It is advised to not use this medicine during an active infection. Use of this medicine should be discontinued after consulting the doctor if a serious infection develops.

Liver Impairment

This medicine should be administered with caution in patients with impaired liver function since it may worsen the condition and aggravate the preexisting clotting disorders. Close monitoring of liver function and coagulation parameters are recommended while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Effects on blood

Use of this medicine may cause a decrease in levels of white blood cells and platelets. Close monitoring of blood cell count is necessary during and after the treatment. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Malignancies

This medicine is known to increase the risk of cancers including lymphoma or lymphoproliferative disorders. Close monitoring of signs and symptoms is necessary. The treatment should be discontinued if malignancy develops.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established. However, your doctor may prescribe this medicine if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any adverse effects.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Leflunomide

Live vaccines

Etanercept

Infliximab

Adalimumab

Deferiprone

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should strictly be administered under qualified healthcare professional with experience of immunosuppressive therapy in the transplant setting. Close monitoring of the patient is recommended during the infusion and until the end of the infusion. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by acting against the white blood cells and suppresses the immunity thereby prevents organ rejection in transplant patients.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Immunoglobulins, Immunosuppressive agents

Schedule

Schedule G

[Internet]. Dailymed.nlm.nih.gov. 2019 [cited 2 January 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bbd8ab99-552e-4b81-aca4-6b0c7af8b9ae

Antithymocyte immunoglobulin (rabbit) - DrugBank [Internet]. Drugbank.ca. 2019 [cited 2 January 2019]. Available from:

https://www.drugbank.ca/drugs/DB00098

[Internet]. Medicines.org.uk. 2019 [cited 2 January 2019]. Available from:

https://www.medicines.org.uk/emc/product/6238#

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Information on this page was last updated on 6 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.