Amrinone

Description

Amrinone is used for the management of congestive heart failure. This medicine is not recommended for use if you are known allergic to it and should be used with extreme caution in patients with an acute phase of myocardial infarction and arrhythmias.

Side effects

Major & minor side effects for Amrinone

  • Low blood pressure
  • Abdominal pain
  • Nausea or Vomiting
  • Diarrhea
  • Dizziness
  • Headache
  • Fever

Uses of Amrinone

What is it prescribed for?

  • Congestive Heart Failure
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 5 to 10 minutes of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 0.5 to 2 hours. It is likely to be changed based on the dose, for multiple doses: 8 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to amrinone, milrinone, any bisulfites or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Myocardial infarction

This medicine should be used with extreme caution in patients with a recent MI (Myocardial infarction) due to the increased risk of worsening of the patient's condition. You may require a dose adjustment and more frequent monitoring of the cardiac functions while receiving this medicine. An alternative treatment option should be considered in some cases based on the clinical condition.

Hypotension

This medicine may lower the blood pressure severely in some patients. Close monitoring of the blood pressure levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Kidney impairment

This medicine should be used with caution in patients with kidney impairment due to the increased risk of adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Electrolyte Abnormalities

This medicine may imbalance the electrolytes levels and therefore should be used with caution in patients with electrolyte abnormalities due to the increased risk of adverse effects. Close monitoring of electrolytes levels is necessary while receiving this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Use in children

The safety and efficacy of this medicine have not been clinically established in children aged below 18 years. However, your doctor may prescribe this medicine if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any adverse effects.

Heart valve disease

This medicine should be used with extreme caution in patients with heart valve disease due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Missed Dose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Selegiline

Disopyramide

Nefazodone

Tizanidine

Linezolid

Disease interactions

Arrhythmias

This medicine should be used with extreme caution in patients with arrhythmias due to the increased risk of worsening of the patient's condition. Regular monitoring of the ECG is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine relaxes and dilates the blood vessels resulting in improved blood flow. It also improves and strengthens the heart function.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Inotropic agents, Phosphodiesterase inhibitor

Schedule

Schedule H

Amrinone - DrugBank [Internet]. Drugbank.ca. 2018 [cited 10 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB01427

[Internet]. 2018 [cited 10 December 2018]. Available from:

https://www.glowm.com/resources/glowm/cd/pages/drugs/ij008.html

Inamrinone [Internet]. Mychart.geisinger.org. 2018 [cited 10 December 2018]. Available from:

https://mychart.geisinger.org/Staywel/html/Drug%20Sheets/26,36.html

Inamrinone [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 10 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Amrinone

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Information on this page was last updated on 1 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.