Ampicillin

Description

Ampicillin is a penicillin-type antibiotic used to treat bacterial infections. This antibiotic is used to treat different types of bacterial infections of the throat, lungs, nose, blood, heart, brain, urinary tract and skin. Ampicillin works by stopping the bacteria to form its cell wall thereby making it weaker and die eventually. This action stops the growth and spread of infection. It is not effective against infections caused by viruses. Side effects of Ampicillin are diarrhoea, stomach pain, headache, weakness, nausea, and vomiting. Inform your doctor if you are allergic to penicillin. Use it cautiously in individuals with kidney problems. Ampicillin can make birth control pills less effective. You may be asked to take a different way of birth control methods to prevent unintended pregnancy. Ampicillin is available on prescription as capsules, tablets, injection, syrup and suspension. You can take Ampicillin around the same time every day for the ease of remembering. For the best results, take this antibiotic at evenly spaced times. Once an antibiotic is started, it is always recommended to finish the entire course of treatment.

Side effects

Major & minor side effects for Ampicillin

  • Diarrhoea
  • Skin rash
  • Pain at the injection site
  • Fever with chills
  • Stomach pain
  • Dizziness
  • Loss of appetite
  • Headache
  • Nausea and vomiting
  • Loss of appetite

Uses of Ampicillin

What is it prescribed for?

  • Bacterial Meningitis
  • Sinusitis
  • Endocarditis
  • Bacterial Septicemia
  • Urinary tract infections
  • Pharyngitis/Tonsilitis
  • Lung infections
  • Skin and soft tissue infections
  • Intra-abdominal Infections
  • Typhoid fever
Read More
Concerns

Commonly asked questions

  • Onset of action
    Ampicillin starts working within 1 to 2 hours after an oral administration. You will start to feel better in 2 to 3 days after taking ampicillin. But finish your entire course of treatment, even if the condition gets better. The effect of ampicillin injection starts immediately after the administration.
  • Duration of effect
    The effect of ampicillin lasts for an average duration of 3 to 6 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendency has been reported for Ampicillin.
  • Usage in pregnancy?
    Ampicillin is generally safe in pregnancy to treat bacterial infections. It is not known to cause birth defects when used by pregnant women. Hence it is acceptable for use upon your doctor's recommendation.
  • Usage while breast-feeding?
    Ampicillin is safe to use during breastfeeding. It is not known to be harmful to breastfeeding women. It passes into breast milk in very low levels that are not expected to cause adverse effects in breastfed infants. Hence it is acceptable for use upon your doctor's recommendation.

Allergy

Avoid taking Ampicillin if you are previously allergic to it. Some patients may get allergic reactions to this medicine. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.
Warnings for special population

Pregnancy

Ampicillin is generally safe in pregnancy to treat bacterial infections. It is not known to cause birth defects when used by pregnant women. Hence it is acceptable for use upon your doctor's recommendation.

Breast-feeding

Ampicillin is safe to use during breastfeeding. It is not known to be harmful to breastfeeding women. It passes into breast milk in very low levels that are not expected to cause adverse effects in breastfed infants. Hence it is acceptable for use upon your doctor's recommendation.
General warnings

Allergic reactions

Ampicillin is likely to cause severe allergic reactions in some people. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or breathing difficulties.

Antibiotic resistance

Finish your entire course of treatment with Ampicillin, even if the condition gets better to avoid antibiotic resistance (the bacteria may become resistant to antibiotics). If you still feel unwell after completing your antibiotic course, make an appointment to consult your doctor.

Diarrhoea

Ampicillin can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Get emergency medical help if you experience severe diarrhoea that is watery or bloody. Call your pharmacist/doctor before taking anti-diarrhoeal medication.

Mononucleosis

Mononucleosis is also called kissing disease is an infection caused by the Epstein-Barr virus. It is spread through saliva. People with mononucleosis may develop a maculopapular skin rash (flat and small raised bumps on the skin) after 5-10 days of treatment with Ampicillin and resolves within days of discontinuing the use. Ampicillin may not be appropriate medicine in patients with mononucleosis.

Driving or operating machinery

Ampicillin may cause dizziness, confusion, or fits in some people. Do not drive a vehicle or operate machinery after taking this medicine.

Missed Dose

Oral forms: Try not to skip a dose of ampicillin. And if a dose is skipped, do not add it up to the next dose. Injection: Ampicillin is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Oral forms: Seek emergency medical attention in case of an overdose with ampicillin. Injection: Since ampicillin injection is administered in the hospital or clinical setting by a qualified healthcare professional, the chances of an overdose are very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Atenolol

Chloroquine

Doxycycline

Methotrexate

Warfarin

Disease interactions

Impaired kidney function

Ampicillin is filtered by the kidney and moved out of the body through urine. Patients with kidney diseases need special consideration while using Ampicillin due to the risk of kidney damage. Dose adjustment should be done based on the clinical condition.

Colitis

Ampicillin can kill the helpful bacteria in your stomach or intestine and leads to diarrhoea. Therefore use Ampicillin with extreme caution in patients with gastrointestinal (mouth to anus) diseases, particularly colitis (swelling of the inner lining of the colon), since it may worsen the patient's condition.
Food interactions
The absorption of Ampicillin may be decreased in the presence of food. For proper absorption of the medicine, it should be taken at least 1 hour before or 2 hours after the meals.
Lab interactions
Information not available.
Ampicillin uses for treating bacterial infections is safe and effective. Oral forms: Take ampicillin 1 hour before or 2 hours after meals. Never take more than the prescribed dose. Do not give your medicine to other people even if their condition appears to be the same as yours. Injection: Ampicillin should be administered by a qualified healthcare professional in a clinic or hospital.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
Ampicillin works by preventing the formation of bacterial cell walls. This helps in stopping the growth and multiplication of the microorganism, eventually killing it.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Aminopenicillins, Antibiotics

Schedule

Schedule H

Dailymed.nlm.nih.gov. 2021. DailyMed - AMPICILLIN- ampicillin sodium injection, powder, for solutionAMPICILLIN- ampicillin sodium injection, powder, for solution. [online] Available at: < [Accessed 17 February 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=da8da9c0-fa46-40d3-82c6-1a18ffa1b585>

Drugs, H., 2021. Ampicillin Injection: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 17 February 2021].

https://medlineplus.gov/druginfo/meds/a601133.html>

Pubchem.ncbi.nlm.nih.gov. 2021. Ampicillin. [online] Available at: < [Accessed 23 March 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Ampicillin>

Go.drugbank.com. 2021. Ampicillin | DrugBank Online. [online] Available at: < [Accessed 23 March 2021].

https://go.drugbank.com/drugs/DB00415>

Dailymed.nlm.nih.gov. 2021. DailyMed - AMPICILLIN capsule. [online] Available at: < [Accessed 17 February 2021].

https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0a66c5c3-63bf-46e3-835e-26b555ab6954>

How will this medicine affect me?

Consult top doctors online and get an answer now
Consult now
Consult now

Looking for a doctor?

Book an appointment with the top doctors near you
Book now
Book now
Something doesn’t feel right?
Report an error

Information on this page was last updated on 23 Mar 2021

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.