Amphotericin B (Liposomal)

Description

Amphotericin B (Liposomal) is an antifungal medicine. It is used to treat serious and life-threatening fungal infections caused by different fungal species. This medicine works by stopping the growth of fungi. Amphotericin B (Liposomal) shows side effects like decreased potassium levels, nausea, vomiting, chills, diarrhoea, weakness, etc. Consult your doctor if any of these side effects do not resolve with time or worsen. Avoid receiving this medicine if you are allergic to it. Amphotericin B (Liposomal) will be administered in a hospital setting by a healthcare professional. Your doctor will decide the dose and duration of treatment based on the severity of the infection. Do not self administer this medicine. Amphotericin B (Liposomal) should be used with caution if you have kidney problems. Inform your doctor if you are taking any other medicines to avoid undesired effects. Inform your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.

Side effects

Major & minor side effects for Amphotericin B (Liposomal)

  • Irregular heart beat
  • Fever and chills
  • Diarrhoea
  • Decreased potassium levels
  • Anaemia
  • Cough
  • Stomach pain
  • Headache
  • Pain at injection site
  • Nausea and Vomiting
  • Chest pain

Uses of Amphotericin B (Liposomal)

What is it prescribed for?

  • Invasive Aspergillosis
  • Candidemia
  • Cryptococcosis
  • Febrile Neutropenia
  • Leishmaniasis
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Concerns

Commonly asked questions

  • Onset of action
    The time Amphotericin B (Liposomal) takes to show its action is not known.
  • Duration of effect
    The amount of time for which Amphotericin B (Liposomal) remains active in your body is not known.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    Amphotericin B (Liposomal) has no habit-forming tendency.
  • Usage in pregnancy?
    As animal studies indicate that Amphotericin B (Liposomal) does not harm the foetus, this medicine may be used during pregnancy upon your doctor's recommendation.
  • Usage while breast-feeding?
    It is not known if Amphotericin B (Liposomal) passes into the breastmilk. If you are breastfeeding, discuss all the risks and benefits associated with this medicine with your doctor before receiving it.

Allergy

Amphotericin B (Liposomal) is not recommended for use if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Warnings for special population

Pregnancy

As animal studies indicate that Amphotericin B (Liposomal) does not harm the foetus, this medicine may be used during pregnancy upon your doctor's recommendation.

Breast-feeding

It is not known if Amphotericin B (Liposomal) passes into the breastmilk. If you are breastfeeding, discuss all the risks and benefits associated with this medicine with your doctor before receiving it.
General warnings

Anaphylaxis

Amphotericin B (Liposomal) may cause serious anaphylactic reactions (an allergic reaction that is serious and life-threatening if not treated immediately). An anaphylactic reaction occurs immediately after receiving any medicine you are allergic to them. Hence, your doctor will monitor you closely while administering this medicine.

Noninvasive fungal infections

Amphotericin B (Liposomal) is not recommended to treat noninvasive fungal infections in people with normal neutrophil (a type of white blood cell) counts.

Infusion reactions

Amphotericin B (Liposomal) may cause infusion reactions such as a headache, fever, chills, loss of appetite, nausea, vomiting, breathing problems, or dizziness with the first few doses. These reactions usually diminish with subsequent doses.

Missed Dose

As Amphotericin B (Liposomal) is administered in the hospital setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

As Amphotericin B (Liposomal) is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by your doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Tacrolimus

Cidofovir

Indapamide

Flucytosine

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Amphotericin B (Liposomal) should be administered in a hospital setting by a qualified healthcare professional. Carefully follow all the instructions given by your doctor. Report to your doctor about all your current medications as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Amphotericin B (Liposomal) works by blocking the action of a vital component of the fungal cell membrane (protective covering). Thus it slows the growth of the fungi.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Polyenes, Antifungals

Schedule

Schedule H

Medicines.org.uk. 2021. [online] Available at: < [Accessed 28 October 2021].

https://www.medicines.org.uk/emc/files/pil.1022.pdf>

Drugs, H., 2021. Amphotericin B Liposomal Injection: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 28 October 2021].

https://medlineplus.gov/druginfo/meds/a616018.html>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 28 October 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050740s016lbl.pdf>

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Information on this page was last updated on 4 Mar 2022

Disclaimer

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