Amphotericin B (Liposomal)

Description

Amphotericin B (Liposomal) is an antifungal medicine used to treat serious and potentially life-threatening infections caused by different fungal species. The liposomal form of this medicine has been shown to be less nephrotoxic than the conventional form. Incidences of infusion-related adverse reactions associated with the liposomal form are also fewer than that of the conventional form.

Side effects

Major & minor side effects for Amphotericin B (Liposomal)

  • Irregular heart beat
  • Fever and chills
  • Diarrhea
  • Decreased potassium levels
  • Anemia
  • Cough
  • Abdominal pain
  • Headache
  • Pain at injection site
  • Nausea and Vomiting
  • Chest pain

Uses of Amphotericin B (Liposomal)

What is it prescribed for?

  • Invasive Aspergillosis
  • Candidemia
  • Cryptococcosis
  • Febrile Neutropenia
  • Cryptococcal Meningitis
  • Leishmaniasis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is recommended for use in pregnant women only if absolutely necessary. Discuss all the risks and benefits with your doctor before using this medicine.
  • Usage while breast-feeding?
    This medicine is relatively safe for use in breastfeeding women. However, all the risks and benefits should be discussed with the doctor before using this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to amphotericin B or any other components present along with it.
Warnings for special population

Pregnancy

This medicine is recommended for use in pregnant women only if absolutely necessary. Discuss all the risks and benefits with your doctor before using this medicine.

Breast-feeding

This medicine is relatively safe for use in breastfeeding women. However, all the risks and benefits should be discussed with the doctor before using this medicine.
General warnings

Anaphylaxis

This medicine may cause serious anaphylactic reactions. Appropriate corrective measures should be undertaken in the event of any anaphylactic reactions. Therapy may be discontinued based on the clinical condition.

Noninvasive fungal infections

This medicine is not recommended to treat noninvasive fungal infections in patients with normal neutrophil counts.

Infusion reactions

This medicine may cause infusion reactions such as a headache, fever, chills, loss of appetite, nausea, vomiting, breathing problems, or dizziness with the first few doses. These reactions usually diminish with subsequent doses.

Rapid intravenous infusion

Rapid intravenous infusion of this medicine should be avoided due to the increased risk of serious adverse effects such as hypotension, hypokalemia, arrhythmias, and shock.

Missed Dose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Tacrolimus

Cidofovir

Indapamide

Flucytosine

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered only by a qualified healthcare professional. Carefully follow all the instructions given by your doctor. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Amphotericin B (Liposomal) works by blocking the action of a certain vital component of the fungal cell wall. This results in disruption of cell membrane and death of the fungus.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Polyenes

Schedule

Schedule H

Amphotericin B - DrugBank [Internet]. Drugbank.ca. 2017 [cited 4 September 2017]. Available from:

https://www.drugbank.ca/drugs/DB00681

[Internet]. 2017 [cited 4 September 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.8363.latest.pdf

Amphotericin B Liposomal Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 7 September 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a616018.html

TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2017 [cited 7 September 2017]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-01027-3&d=2017090716114622483

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Information on this page was last updated on 9 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.