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Terlipressin
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Description
Terlipressin is used for the treatment of bleeding esophageal varices (dilated blood vessels of the esophagus) and type 1 hepatorenal syndrome (progressive kidney failure in people with severe liver damage). This medicine is not recommended for use in children.
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Side effects
Major & minor side effects for Terlipressin
Headache
Abdominal cramps
Nausea
Diarrhea
Pale skin
Chest pain
Shortness of breath
Vomiting
Irregular heartbeat
Increased blood sugar levels
Uses of Terlipressin
What is it prescribed for?
Bleeding Esophageal Varices
This medicine is used to treat the bleeding of dilated blood vessels of the esophagus which develops when the blood flow to the liver is reduced due to a blood clot within the liver or scar tissue.
Type 1 Hepatorenal Syndrome
This medicine is used in the treatment of type 1 hepatorenal syndrome (progressive kidney failure in people with severe liver damage) characterized by rapid kidney failure and an increase in the levels of creatinine.
Concerns
Commonly asked questions
Onset of action
The amount of time required for this medicine to show its action is not clinically established.Duration of effect
The amount of time for which this medicine remains active in the body is not clinically established.Safe with alcohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is it habit forming?
No habit-forming tendencies were reported.Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
Allergy
This medicine is not recommended for use in patients with a known allergy to terlipressin or any other inactive ingredients present along with it.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings
Septic shock
This medicine should be used with extreme caution in patients with septic shock due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Chronic kidney impairment
This medicine should be used with extreme caution in patients with an impaired kidney function due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Heart disorders
This medicine should be used with caution in patients with heart disorders such as arrhythmias, acute coronary syndrome, or recent myocardial infarction, etc due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Cerebral or peripheral vascular disorders
This medicine should be used with caution in patients with cerebral or peripheral vascular disorders due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Use in elderly
This medicine should be used with caution in patients aged above 70 years due to the increased risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Use in children
This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.
Missed Dose
Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of a missed dose is very less.
Overdose
Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Aliskiren
antihistamines
Propofol
Erythromycin
Tricyclic Antidepressants
Class IA & III Antiarrythmic agents
Disease interactions
Disease
Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine.
Miscelleneous
How it works
It works by narrowing the affected blood vessels and restricts the blood flow.
Legal Status
Classification
Category
Vasoconstrictor
Schedule
Schedule H
Terlipressin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 20 September 2018]. Available from:
Terlipressin acetate 0.12 mg/ml solution for injection - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 20 September 2018]. Available from:
Terlipressin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 20 September 2018]. Available from:
[Internet]. Tga.gov.au. 2018 [cited 20 September 2018]. Available from:
[Internet]. Medsafe.govt.nz. 2018 [cited 20 September 2018]. Available from:
Information on this page was last updated on 16 May 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.