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Micafungin

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Description

Micafungin is an antifungal medicine used for the treatment of fungal infections of the stomach, blood, lungs, and oesophagus. It is also used for the prevention of fungal infections in people undergoing stem cell transplantation. This medicine binds with the fungus cell and kills them. Micafungin can cause side effects like nausea, vomiting, cough, loss of appetite, etc. Consult your doctor if these side effects are worsening or getting persistent. Avoid driving vehicles and operating machines after receiving this medicine as it can make you feel drowsy. Micafungin is administered by a qualified healthcare professional in a clinic or a hospital. Your dose and duration of the treatment will be decided on the basis of the severity of your condition. Do not stop receiving this medication without consulting your doctor as your symptoms could reoccur. Micafungin is not recommended if you are allergic to it. Inform all your current medications and pre-existing medical conditions to your doctor before receiving this medicine. This will help your doctor to adjust your dose for avoiding any side effects. If you are pregnant or breastfeeding, inform your doctor before receiving this medicine.
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Side effects

Major & minor side effects for Micafungin

Black or tarry stools

Cough

Fever or chills

Increased thirst

Loss of appetite

Nausea or vomiting

Pale skin

Shortness of breath

Weight gain

Drowsiness

Bone pain

Blurred vision

Headache

Diarrhoea

Uses of Micafungin

What is it prescribed for?

Esophageal Candidiasis

Candidiasis is a fungal infection caused by a yeast (a type of fungus) called Candida. Micafungin is used to treat fungal infections of the oesophagus caused by Candida species.

Candidemia

Candidemia is a condition where the fungi of the Candida species are present in the blood causing infection. It spreads to other parts of the body quickly and affects it. Micafungin is used to treat this condition.

Acute disseminated candidiasis

Acute disseminated candidiasis, or invasive candidiasis, is a fungal infection of the Candida species. It usually presents as candidemia (presence of candida fungi in the blood) and progresses to several organs like the liver, kidney, spleen, eyes, brain, and heart. Micafungin is used to treat this condition.

Candida Peritonitis and abscesses

Peritonitis is inflammation of the peritoneum — a silk-like membrane that lines your inner abdominal wall and covers the organs within your abdomen — that is usually due to a bacterial or fungal infection. Micafungin is used for the treatment of peritonitis caused by fungal infections.

Prophylaxis in Hematopoietic Stem Cell Transfer (HSCT) patients

Micafungin is used for preventing fungal infections in people undergoing hematopoietic stem cell transplantation (HSCT). It is the transplantation of a special kind of stem cell (special human cells that are able to develop into many different cell types), usually derived from bone marrow to treat conditions like cancer.

Aspergillosis

Aspergillosis is a common mould (fungus) that we inhale without getting sick. However, individuals having weakened immune systems or lung disorders are at higher risk of developing an infection. This infection spreads to other parts of the body such as the brain, heart, kidney or skin. Micafungin is used to treat this condition.
Concerns

Commonly asked questions

  • Onset of action

    The amount of time required for Micafungin to show its action is not clinically established.

  • Duration of effect

    Micafungin can remain in your body for 3 to 4 days.

  • Safe with alcohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendency has been reported for Micafungin.

  • Usage in pregnancy?

    Micafungin is unsafe for use during pregnancy as it can harm your developing foetus. Hence, consult your doctor if you are pregnant.

  • Usage while breast-feeding?

    Due to the lack of relevant safety information, Micafungin is not recommended for use while breastfeeding. Consult your doctor if you are breastfeeding.

Allergy

Micafungin is not recommended if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Warnings for special population

Pregnancy

Micafungin is unsafe for use during pregnancy as it can harm your developing foetus. Hence, consult your doctor if you are pregnant.

Breast-feeding

Due to the lack of relevant safety information, Micafungin is not recommended for use while breastfeeding. Consult your doctor if you are breastfeeding.

General warnings

Use in children

Micafungin is not recommended for use in children less than 4 months of age as the safety and efficacy of use are not clinically established.

Missed Dose

Since Micafungin is administered by a qualified healthcare professional in the hospital or clinical setting, the likelihood of missing a dose is very low.

Overdose

Since Micafungin is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Sirolimus

Amphotericin B

Disease interactions

Liver Disease

Micafungin is broken down and absorbed in the liver. Therefore, a damaged liver will not break it down properly, resulting in toxicity. Your doctor can adjust your dose or replace it with another medicine according to your condition.

Renal Disease

Micafungin is filtered by your kidneys. If you have kidney problems, this medicine will not get filtered properly, therefore increasing the risk of toxicity. Your doctor can adjust the dose while monitoring your condition closely or suggest another medicine if required.

Anaemia

Anaemia is a condition in which the number of red blood cells or the haemoglobin concentration within them is lower than normal. Micafungin can cause anaemia in some people. Therefore, your doctor will closely monitor your blood cells while you are receiving this medicine.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Micafungin is usually administered by a qualified healthcare professional in the hospital or clinical setting. Inform the doctor if you have a known allergy to this medicine. Consult your doctor if you experience any change of colour in your urine or any other side effects.

Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works

Micafungin slows the growth of the fungi and kills the fungi that cause the infection.

Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Echinocandins

Schedule

Schedule H

Astellas.us. 2022. [online] Available at: < [Accessed 1 March 2022].

https://www.astellas.us/docs/mycamine.pdf>

Accessdata.fda.gov. 2022. [online] Available at: < [Accessed 1 March 2022].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021506s009lbl.pdf>

Ema.europa.eu. 2022. [online] Available at: < [Accessed 1 March 2022].

https://www.ema.europa.eu/documents/product-information/mycamine-epar-product-information_en.pdf>

Dailymed.nlm.nih.gov. 2022. DailyMed - MYCAMINE- micafungin sodium injection, powder, lyophilized, for solution. [online] Available at: < [Accessed 1 March 2022].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bc234dd7-5221-4a68-b153-aa0393c75bbf>

Medicines.org.uk. 2022. Mycamine 100 mg powder for concentrate for solution for infusion - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 1 March 2022].

https://www.medicines.org.uk/emc/product/7528/smpc>
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Information on this page was last updated on 6 Jan 2023

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.