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Lami Plus Tablet
Manufactured byMCNEIL & ARGUS PHARMACEUTICALS LTD
ContainsLamivudine (150 mg) + Zidovudine (300 mg) + Nevirapine (200 mg)
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Description
Lami Plus Tablet is a combination medicine which is used to treat human immunodeficiency virus (HIV) infections in patients weighing at least 35 kg. This medicine is not a cure for HIV. It only prevents the virus from multiplying in your body. Monitoring of liver function and kidney function may be necessary while receiving this medicine based on the clinical condition of the patient.
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Substitutes
List of substitutes for Lami Plus Tablet
Side effects
Major & minor side effects for Lami Plus Tablet
Chills and fever
Headache
Tiredness
Loss of appetite
Depression
Stuffy nose
Indigestion
Sore throat
Pale skin
Diarrhea
Nausea and Vomiting
Difficulty with bowel movements
Weight loss
Heartburn
Abdominal and stomach cramps
Dark colored urine
Skin Rash
Muscle pain and cramps
Uses of Lami Plus Tablet
What is it prescribed for?
HIV infection
This medicine is used for the treatment of human immunodeficiency virus (HIV) infection in patients weighing at least 35 kg and who have been stabilized on the maintenance regimen of nevirapine 200 mg twice a day.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The amount of time required for this medicine to show its action is not clinically established.How long do the effects of this medicine last?
The amount of time for which this medicine remains active in the body is not clinically established.Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is this a habit forming medicine?
No habit forming tendency has been reported.Can this medicine be taken during pregnancy?
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.Can this medicine be taken while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to lamivudine, zidovudine, nevirapine or any other inactive ingredients present along with the formulation.
Moderate to severe liver impairment
This medicine is not recommended for use in patients with a moderate to severe liver impairment due to the increased risk of worsening of the patient's condition.
Post-exposure prophylaxis
This medicine is not recommended for use in post-exposure prophylaxis treatment for HIV infection.
Kidney impairment
This medicine is not recommended for use in patients with creatinine clearance less than 50 ml/min due to the increased risk of serious adverse effects.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings
Immune reconstitution syndrome
This medicine should be used with caution due to the increased risk of Immune reconstitution syndrome. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Liver diseases
This medicine should be used with extreme caution in patients with mild liver impairment due to the increased risk of worsening of the patient's condition. Liver function should be assessed before initiating the treatment. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition. This medicine is not recommended for use in patients with a moderate to severe liver impairment.
Pancreatitis
This medicine may rarely cause pancreatitis in some patients. Report any unusual symptoms to the doctor immediately. Therapy may need to be discontinued if the patient develops any signs or symptoms of pancreatitis.
Lactic acidosis
This medicine should be used with caution due to the increased risk of Lactic acidosis. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Fat redistribution
This medicine may cause fat gain or fat loss from the body. This may result in peripheral wasting, facial wasting, breast enlargement, and Cushingoid appearance. Close monitoring of body weight and body fat distribution is necessary while receiving this medicine. Any changes in the body should be informed to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Skin rash
This medicine should be used with caution due to the increased risk of serious and life-threatening skin reactions. Seek emergency medical treatment in case of any unusual reactions such as rashes or blisters. Therapy with this medicine may need to be discontinued based on the clinical condition of the patient.
Driving or operating machinery
This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Missed Dose
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Clarithromycin
Clozapine
Methotrexate
Atazanavir
Atorvastatin
Etodolac
Ganciclovir
Fenofibrate
Efavirenz
Disease interactions
Bone marrow suppression
This medicine should be used with caution in patients with a known history of bone marrow suppression due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Myopathy
This medicine should be used with caution in patients with a known history of myopathy due to the increased risk of worsening of the patient's condition. Report any symptoms such as dark-colored urine, muscle pain, weakness, etc. to the doctor immediately. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Renal Dysfunction
This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Liver impairment
This medicine should be used with extreme caution in patients with mild liver impairment due to the increased risk of worsening of the patient's condition. Liver function should be assessed before initiating the treatment. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition. This medicine is not recommended for use in patients with a moderate to severe liver impairment.
Pancreatitis
This medicine may cause pancreatitis in some patients. Report any unusual symptoms to the doctor immediately. Therapy may need to be discontinued if the patient develops any signs or symptoms of pancreatitis.
Skin Rash
This medicine should be used with extreme caution due to the increased risk of serious and life-threatening skin reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and hypersensitivity reactions characterized by a rash. Seek emergency medical treatment in case of any unusual reactions such as a rash or blisters. Replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller quantities than recommended. Ensure that proper hygiene measures are adopted. Complete the course of treatment to prevent the spread of the infection. Close monitoring of liver function and kidney function may be necessary while receiving this medicine based on the clinical condition.
Miscelleneous
How it works
This medicine works by stopping the human immunodeficiency virus (HIV) from multiplying. This helps in reducing the chances of development of acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses.
Legal Status
Classification
Category
Antiviral combinations
Schedule
Schedule H
[Internet]. Hivdb.stanford.edu. 2019 [cited 1 April 2019]. Available from:
[Internet]. Extranet.who.int. 2019 [cited 1 April 2019]. Available from:
Duovir-N Tablets [Internet]. CiplaMed. 2019 [cited 1 April 2019]. Available from:
Lamivudine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 29 August 2017]. Available from:
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Information on this page was last updated on 10 Jul 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.