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Disopyramide
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Description
Disopyramide is an anti-arrhythmic medicine which is used to treat an irregular heartbeat. It belongs to a group of medicines called Class 1A antiarrhythmic agents.
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Side effects
Major & minor side effects for Disopyramide
Dizziness
Fainting
Shortness of breath
Unusal tiredness
Blurred vision
Constipation
Dry eyes, mouth, nose or throat
Chest pain
Fast or slow heartbeat
Lightheadedness
Rash or Itching
Low blood sugar levels
Yellowing of skin or eyes
Uses of Disopyramide
What is it prescribed for?
Arrhythmias
This medicine is used for the treatment of rhythm disorders characterized by the irregular beating of the heart. This is caused due to an imbalance in ions that generate electrical impulses.
Concerns
Commonly asked questions
Onset of action
The effect of this medicine can be observed within 30 min to 3.5 hours of administration of the dose.Duration of effect
The effect of this medicine lasts for an average duration of 1.5 to 8.5 hours.Safe with alcohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is it habit forming?
No habit-forming tendencies were reported.Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If this medicine is used, close monitoring of the infant for any undesired side effects is recommended.
Allergy
This medicine is not recommended for use if you have a known allergy to disopyramide or any other ingredients present along with it.
Cardiogenic shock
This medicine is not recommended for use in patients with cardiogenic shock due to the risk of worsening of the patient's condition.
Heart block greater than first degree
This medicine is not recommended for use in patients with second or third-degree heart block due to the risk of worsening of the patient's condition.
Congenital QT syndrome
This medicine is not recommended for use in patients with congenital QT syndrome due to the risk of worsening of the patient's condition.
Sick sinus syndrome
This medicine is not recommended for use in patients with sick sinus syndrome (heart rhythm disorder) due to the risk of worsening of the patient's condition.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If this medicine is used, close monitoring of the infant for any undesired side effects is recommended.
General warnings
Electrolyte abnormalities
This medicine should be used with extreme caution in patients having an electrolyte imbalance in the body. An altered level of ions like magnesium and sodium affects the absorption of this medicine, reducing effectiveness. Hence, the electrolyte imbalance should be corrected in such patients before starting therapy with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition
Kidney impairment
This medicine should be used with extreme caution in patients with kidney impairment due to the increased risk of severe adverse effects. Regular monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Liver impairment
This medicine should be used with extreme caution in patients with liver impairment due to the increased risk of severe adverse effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Hypotension
This medicine may cause hypotension (low blood pressure) and hence should be used with caution in patients with low blood pressure due to increased risk of worsening of the patient's condition. Regular monitoring of blood pressure levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Use in elderly population
This medicine should be used with extreme caution in elderly patients due to the risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
QT Prolongation
This medicine may cause prolongation of the QT interval and worsen the patient's condition. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Hypoglycemia
This medicine may cause hypoglycemia (low blood sugar levels) in some patients. Regular monitoring of blood sugar levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Driving and operating machinery
This medicine may cause symptoms such as dizziness, fainting, blurred vision, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Missed Dose
The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Amitriptyline
Ondansetron
Ciprofloxacin
Lidocaine
Amiodarone
Clarithromycin
Chlorpromazine
Disease interactions
Electrolyte imbalance
This medicine should be used with caution in patients having an electrolyte imbalance in the body. An altered level of ions like magnesium and sodium affects the absorption of this medicine, reducing effectiveness.
Heart disease
This medicine should be used with extreme caution in patients suffering from any heart disease that affects the blood pumping capacity and the normal rhythm. An alternate therapy should be considered based on the diagnosis made.
Food interactions
Consumption of grapefruit juice or grapefruit is not recommended while taking this medicine due to increased risk of adverse effects. Any unusual symptoms should be reported to the doctor immediately.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
This medicine works by modifying the electrical impulses in the heart, making it more resistant to abnormal activity.
Legal Status
Classification
Category
Group I antiarrhythmics
Schedule
Schedule H
[Internet]. Drugbank.ca. 2018 [cited 10 December 2018]. Available from:
[Internet]. Medlineplus.gov. 2018 [cited 10 December 2018]. Available from:
[Internet]. Dailymed.nlm.nih.gov. 2018 [cited 10 December 2018]. Available from:
[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 10 December 2018]. Available from:
Information on this page was last updated on 9 May 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.