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Dapsone (GSK) 25 mg Tablet

Manufactured byGlaxosmithkline Pharmaceuticals Ltd.
ContainsDapsone
CURRENTLY UNAVAILABLE

Description

Dapsone (GSK) 25 mg Tablet is an antibacterial agent used along with other medicines (multi-drug regimen) for the treatment of all forms of leprosy, a long-term infection caused by Mycobacterium leprae or Mycobacterium lepromatosis. It may also be used to treat dermatitis herpetiformis, a chronic blistering skin condition characterized by blisters filled with watery fluid and intense itching.
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Substitutes

List of substitutes for Dapsone (GSK) 25 mg Tablet

Side effects

Major & minor side effects for Dapsone (GSK) 25 mg Tablet

Nausea and vomiting

Sore throat

Stomach upset

Convulsions

Dizziness

Loss of appetite

Skin rash

Fever

Yellowing of skin and eyes

Discoloration of urine, feces, sputum, sweat

Uses of Dapsone (GSK) 25 mg Tablet

What is it prescribed for?

Leprosy

This medicine is used to treat leprosy, a long-term infection caused by Mycobacterium leprae or Mycobacterium lepromatosis, characterized by the loss of parts of extremities due to repeated injuries or unnoticed wounds. This medicine is used in combination with rifampicin and clofazimine to treat leprosy.

Dermatitis herpetiformis

This medicine may be used to treat dermatitis herpetiformis, a chronic blistering skin condition characterized by blisters filled with watery fluid and intense itching. With this treatment, the itching is reduced within 2-3 days.
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?

    The amount of time required for this medicine to show its action is not clinically established.

  • How long do the effects of this medicine last?

    The amount of time for which this medicine remains active in the body is not clinically established.

  • Is it safe to consume alcohol while taking this medicine?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is this a habit forming medicine?

    No habit forming tendencies were reported.

  • Can this medicine be taken during pregnancy?

    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

  • Can this medicine be taken while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired effects is necessary. Your doctor may advise you to stop breastfeeding or to stop the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to dapsone or sulfonamides, sulfones, or any other components present with the formulation.

Porphyria

This medicine is not recommended for use in patients with porphyria (build-up of a chemical called porphyrin in the body) due to the increased risk of worsening of the patient's condition.

Severe anemia

This medicine is not recommended for use in patients with severe anemia due to the increased risk of worsening of the patient's condition.

Severe glucose-6-phosphate dehydrogenase deficiency

This medicine is not recommended for use in patients with severe glucose-6-phosphate dehydrogenase deficiency due to the increased risk of worsening of the patient's condition.

Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired effects is necessary. Your doctor may advise you to stop breastfeeding or to stop the medicine based on your clinical condition.

General warnings

Allergic reactions

This medicine may cause a skin rash, photosensitivity reactions, severe itching, etc. in some patients. Serious skin hypersensitivity reactions may also occur rarely including Stevens-Johnson syndrome, toxic epidermal necrolysis, maculopapular rash, exfoliative dermatitis, etc. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Lab tests

Regular lab tests including complete blood counts should be performed to monitor the adverse effects of this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Secondary infection

Long term or repeated use of this medicine may cause secondary infections. Report any signs of secondary infection to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Methemoglobinemia

This medicine should be used with caution in patients with methemoglobin reductase deficiency due to the increased risk of hemolytic anemia, a condition in which the red blood cells are destroyed. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Glucose-6-phosphate deficiency

This medicine should be used with caution in patients with G6PD (Glucose-6-phosphate dehydrogenase) deficiency due to the increased risk of hemolytic anemia, a condition in which the red blood cells are destroyed. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition. It is not recommended for use in patients with severe glucose-6-phosphate dehydrogenase deficiency.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next scheduled dose then the missed dose should be skipped.

Overdose

Seek emergency medical treatment or contact a doctor immediately in the case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Diltiazem

Amiodarone

Sodium Nitrite

Deferiprone

Live cholera vaccine

Disease interactions

Liver disease

This medicine should be used with caution in patients with liver diseases due to the risk of adverse effects. Close monitoring of the liver function, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Strictly follow the instructions on the label and use this medicine only as directed. Do not use more than what is prescribed or share this medication with other people. It is advised that you should inform the doctor about all the medicines or herbal products that you are using and about all your medical conditions before using this medicine. You are advised to complete the prescribed course even if the symptoms get better.

Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works

This medicine works by blocking the production of certain components necessary for the bacteria to divide and increase in numbers.

Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Leprostatics

Schedule

Schedule H

Dapsone 100 mg Tablets BP - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2020 [cited 4 June 2020]. Available from:

https://www.medicines.org.uk/emc/product/5769/smpc

Dapsone Tablets, USP 25 mg and 100 mg [Internet]. Dailymed.nlm.nih.gov. 2020 [cited 4 June 2020]. Available from:

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=7fc98c9b-b17a-f66f-055b-259207ad9504&type=display

Dapsone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 4 June 2020]. Available from:

https://medlineplus.gov/druginfo/meds/a682128.html

[Internet]. Medsafe.govt.nz. 2020 [cited 4 June 2020]. Available from:

https://www.medsafe.govt.nz/Consumers/cmi/d/DapsoneLink.pdf

[Internet]. Pdf.hres.ca. 2020 [cited 4 June 2020]. Available from:

https://pdf.hres.ca/dpd_pm/00047474.PDF

[Internet]. India-pharma.gsk.com. 2020 [cited 23 June 2020]. Available from:

https://india-pharma.gsk.com/media/701153/dapsone.pdf

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Information on this page was last updated on 23 Jun 2020

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.