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Combither At 120 MG Injection
Manufactured byAristo Pharmaceuticals Pvt. Ltd.
ContainsArtesunate
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Description
Combither At 120 MG Injection is an anti-malarial medicine used for the treatment of severe malaria. It is caused by parasites (organisms living in another organism and causing harm), namely Plasmodium falciparum. Combither At 120 MG Injection is sometimes used in combination with other anti-malarial medicines for treating different types of malarial parasites. It is a primary drug of choice when other anti-malarial medicines are ineffective.
Combither At 120 MG Injection mainly inhibits the final step of the malarial cycle in humans which is responsible for the spread of the infection. Combither At 120 MG Injection may sometimes cause certain side-effects such as dizziness, diarrhoea, belly pain, nausea, and pain at the injection site, etc. Inform your doctor if you experience any of these side effects. This medicine is not recommended for use if you are allergic to it.
Combither At 120 MG Injection should be administered by a healthcare professional in a clinical setting. Combither At 120 MG Injection is given only when oral administration is not possible. Sometimes, this medicine may be followed by the oral form (tablets or capsules) of anti-malarial medicines when recovery is seen after the injection. Your doctor may monitor your blood tests to detect the presence of malarial parasites.
Combither At 120 MG Injection can be given to both adults and children. Inform your doctor if you have/had any medical conditions such as liver, kidney or heart problems etc. and also about other medications being taken before receiving Combither At 120 MG Injection. Inform your doctor if you are pregnant, planning a pregnancy or are breastfeeding.
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Substitutes
List of substitutes for Combither At 120 MG Injection
Falcigo 120 MG Injection
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Falcinil Forte 120 MG Injection
Zuventus Healthcare Ltd.
Larinate 120 MG Injection
Ipca Laboratories Pvt. Ltd.
Match Ar 120 MG Injection
Mankind Pharmaceuticals Ltd.
Side effects
Major & minor side effects for Combither At 120 MG Injection
Dizziness
Headache
Stomach pain
Diarrhoea
Injection site pain
Fever with body pain
Anemia
Low WBC and Platelet count
Chills or shivering
Dark or Clay colored stools
Rapid weight gain
Uses of Combither At 120 MG Injection
What is it prescribed for?
Malaria
Malaria is an infection that occurs when the infected mosquito bites a human. The Plasmodium strain can enter the human body through the blood and invades the red blood cells resulting in the spread of the infection. This condition is mainly characterised by increased body temperature, continuous shivering along with chills, etc. Combither At 120 MG Injection is mainly effective in treating malaria caused by Plasmodium falciparum strain of the parasite. This medicine is sometimes also used in the treatment of malaria that is resistant to other medicines.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The time required for Combither At 120 MG Injection to show its action is 8-12 minutes. However, the time taken depends on whether the injection is given intravenously (into the vein) or intramuscularly (into the muscle).How long do the effects of this medicine last?
Combither At 120 MG Injection remains active in the body for an average duration of 7-8 hours.Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is this a habit forming medicine?
Combither At 120 MG Injection has no habit forming tendencies.Can this medicine be taken during pregnancy?
The exact effect of Combither At 120 MG Injection on pregnant women is not clearly known. Therefore, this medicine should be taken only in life-threatening situations upon your doctors prescriptionCan this medicine be taken while breast-feeding?
Combither At 120 MG Injection is known to pass into breast milk. The breastfed infant may vomit. Discuss the benefits and risks with your doctor before receiving this medicine. The clinical condition of your infant needs to be monitored if you are breastfeeding while receiving this medicine.
Allergy
Avoid taking Combither At 120 MG Injection if you are allergic to it. Seek immediate medical attention if you notice any symptoms of serious allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.
Warnings for special population
Pregnancy
The exact effect of Combither At 120 MG Injection on pregnant women is not clearly known. Therefore, this medicine should be taken only in life-threatening situations upon your doctors prescription
Breast-feeding
Combither At 120 MG Injection is known to pass into breast milk. The breastfed infant may vomit. Discuss the benefits and risks with your doctor before receiving this medicine. The clinical condition of your infant needs to be monitored if you are breastfeeding while receiving this medicine.
General warnings
Post-treatment hemolysis
In some individuals, treatment with Combither At 120 MG Injection may result in hemolytic anaemia (a condition where there is excessive destruction of RBC) which can be observed after 4 hours of giving the medication. Complete Blood count tests may be required in such individuals.
Liver/kidney impairment
Combither At 120 MG Injection may affect your liver/kidney. Your doctor will suggest tests to monitor your liver/kidney functions while you receive this injection. If the damage is severe, then the use of this medicine should be avoided.
Driving or Operating machinery
In some patients Combither At 120 MG Injection may cause dizziness, or drowsiness and hence do not perform activities such as driving vehicles or operating machines if you experience any of these symptoms.
Administration
The injection should only be given by a healthcare professional in a clinical setting.
Missed Dose
Since Combither At 120 MG Injection is given in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.
Overdose
Since Combither At 120 MG Injection is given in a hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Antiretroviral drugs
Phenytoin
Diclofenac
Disease interactions
Liver disease
Caution should be taken when higher doses of Combither At 120 MG Injection is given in people with liver problems. It may worsen the compromised liver. Appropriate diagnostic tests and laboratory investigations will be performed by your doctor before determining the dose regimen.
Kidney Disease
Use of Combither At 120 MG Injection in people with impaired kidney problem should be done with caution as it may worsen the compromised kidney condition. Kidney function tests should be performed on monthly basis to avoid serious health issues.
Food interactions
Information not available.
Lab interactions
Information not available.
Follow all the instructions advised by your doctor while taking Combither At 120 MG Injection.
A qualified healthcare professional should give this medication in the hospital setting.
Inform your doctor if you are allergic to Combither At 120 MG Injection.
Do not start or continue the treatment on your own.
Consult your doctor if you are in the first 3 months of pregnancy or if you are breastfeeding.
Avoid driving or operating machines after taking it because you may feel sleepy.
Inform your doctor if you notice flu-like symptoms such as chills, fever, muscle pains and any changes in the heartbeat.
You may be asked for regular blood tests once a week while taking this medicine.
Miscelleneous
How it works
Combither At 120 MG Injection works by inhibiting protein synthesis in the final stage of the malaria cycle conversion in humans. Thus destroys the parasite and prevent the recurrence of the disease.
Legal Status
Classification
Category
Antimalarial agents
Schedule
Schedule H
Pubchem.ncbi.nlm.nih.gov. 2021. Artesunate. [online] Available at: < [Accessed 3 August 2021].
MALARIA, T., 2021. TREATMENT OF SEVERE MALARIA. [online] Ncbi.nlm.nih.gov. Available at: < [Accessed 3 August 2021].
MCW Healthcare | Innovating for Better Healthcare. 2021. TeSunate Injection | MCW Healthcare. [online] Available at: < [Accessed 3 August 2021].
Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 3 August 2021].
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Information on this page was last updated on 6 Oct 2021
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.