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Cilastatin
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Description
Cilastatin is a dehydropeptidase inhibitor that is used in a combination with imipenem to increase its effectiveness. This combination is used in treating infections such as lower respiratory tract infections, urinary tract infections, intraabdominal infections, bacterial septicemia, etc. caused by various types of bacteria.
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Side effects
Major & minor side effects for Cilastatin
Nausea
Vomiting
Rash
Hives
Itching of skin
Uses of Cilastatin
What is it prescribed for?
Lower Respiratory Tract Infection
This medicine is used in a combination with imipenem for the treatment of lower respiratory tract infections such as pneumonia, acute bronchitis, etc.
Urinary Tract Infection
This medicine is used in a combination with imipenem for the treatment of urinary tract infections.
Intra-abdominal Infection
This medicine is used in a combination with imipenem for the treatment of intra-abdominal infections caused by bacteria such as Escherichia coli, S. epidermidis, etc.
Bacterial Septicemia
This medicine is used in a combination with imipenem for the treatment of bacterial septicemia, a condition in which a bacterial infection elsewhere in the body enters the bloodstream.
Bone and Joint infections
This medicine is used in a combination with imipenem for the treatment of bone and joint infections caused by bacteria such as Staphylococcus aureus, Enterococcus species, etc.
Endocarditis
This medicine is used in a combination with imipenem for the treatment of endocarditis, an infection of the heart's valves or inner lining of the heart chambers.
Skin and Skin Structure Infection
This medicine is used in a combination with imipenem for the treatment of skin and skin structure infections such as cellulitis, wound infections, etc. caused by susceptible strains of bacteria.
Concerns
Commonly asked questions
Onset of action
The amount of time required for this medicine to show its action is not clinically established.Duration of effect
The amount of time for which this medicine remains active in the body is not clinically established.Safe with alcohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is it habit forming?
No habit-forming tendencies were reported.Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
Allergy
This medicine is not recommended for use in patients with a known allergy to cilastatin or any other inactive ingredients present along with it.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings
Missed Dose
Since this medicine is administered by a qualified healthcare professional in the clinic or hospital setting, the likelihood of a missed dose is very low.
Overdose
Since this medicine is administered in the hospital or clinic setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Doxepin
Abacavir
Diltiazem
Cyclosporine
Disease interactions
Disease
Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered only by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesired side effects to the doctor immediately.
Miscelleneous
How it works
This medicine prevents the breakdown of imipenem in the kidneys and thus increases its effectiveness.
Legal Status
Classification
Category
Dehydropeptidase inhibitor
Schedule
Schedule H
Cilastatin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 11 April 2018]. Available from:
Cilastatin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 11 April 2018]. Available from:
[Internet]. Accessdata.fda.gov. 2018 [cited 11 April 2018]. Available from:
Information on this page was last updated on 30 Apr 2018
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.