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Buserelin
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Description
Buserelin is used for the treatment of hormone-dependent advanced cancer of the prostate. It is also used either alone or in a combination with other medicines to treat certain hormone-dependent conditions such as endometriosis and infertility (assisted reproduction -IVF). This medicine is not recommended for use in patients less than 18 years of age.
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Side effects
Major & minor side effects for Buserelin
Headache
Unusual tiredness or weakness
Sleep disturbances
Swelling of the face, arms, hands, lower legs, or feet
Constipation
Nausea or vomiting
Decrease in sexual drive
Vaginal dryness and irritation
Excessive menstrual bleeding
Acne
Back pain
Nasal irritation
Bone and joint pain
Difficult or painful urination
Mild to moderate depression
Dizziness
Increase in blood pressure
Increase in blood glucose level
Anemia
Pain,swelling, and itching at the injection site
Decreased bone density
Fast/irregular heart beat
Impotence
Uses of Buserelin
What is it prescribed for?
Prostate cancer
This medicine is used for the treatment of advanced hormone-dependent cancer of the prostate. However, it should not be used in cases where the testicles are surgically removed (bilateral orchiectomy).
Endometriosis
This medicine is used for the treatment of endometriosis, a painful condition where the tissue that normally lines the wall of the uterus grows outside of it. However, it should be used only in cases where surgery is not necessary.
Assisted reproductive technique
This medicine is also used in a combination with other medicines to treat infertility. Administration of this medicine is followed by synthetic hormones to artificially stimulate ovulation.
Concerns
Commonly asked questions
Onset of action
The amount of time taken by this medicine to show its initial effect is subject to variations based on the condition being treated and individual constitution.Duration of effect
The amount of time for which this medicine remains effective in the body is subject to variations based on the condition being treated and individual constitution.Safe with alcohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is it habit forming?
No habit-forming tendencies were reported.Usage in pregnancy?
This medicine is not recommended for use in pregnant women.Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women.
Allergy
This medicine is not recommended for use in patients with a known allergy to buserelin or any other inactive ingredients present in the formulation.
Non-hormonal-dependent prostate cancer
This medicine is not recommended for use for the treatment of prostate cancer that is not hormone dependent.
Orchiectomy
This medicine is not recommended for the treatment of prostate cancer in patients who have had a surgery to remove the testicles.
Undiagnosed vaginal bleeding
This medicine is not recommended for use in women with an undiagnosed vaginal bleeding.
Pregnancy
This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm.
Lactation
This medicine is not recommended for use while breastfeeding.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women.
Breast-feeding
This medicine is not recommended for use in breastfeeding women.
General warnings
Other medicines
This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you report the use of all your current medicines, including any herbs and supplements, to the doctor before beginning treatment with this medicine.
Pediatric use
This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.
Anemia
This medicine should be used with caution in patients suffering from anemia, with a history of anemia, or predisposed to anemia. Close monitoring of complete blood cell counts is recommended for these patients. Report any signs and symptoms such as unusual tiredness or weakness, pale skin, shortness of breath, etc. to your doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Hypertension
This medicine should be used with caution in patients suffering from a high blood pressure (hypertension) due to the increased risk of a very high blood pressure. Close monitoring of blood pressure levels is advised in these patients. Therapy with this medicine should not be initiated if the blood pressure is uncontrolled. Replacement with a suitable alternative may be necessary based on the clinical condition.
Diabetes
This medicine should be used with caution in patients suffering from diabetes mellitus due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Depression
This medicine should be used with caution in patients with a history of depression and other psychiatric disorders resulting in depression since it may worsen the patient's condition. Close monitoring of the patient for any changes in behavior or mood is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the patient's clinical condition.
Driving vehicles and operating machinery
Use of this medicine may cause symptoms such as dizziness, difficulty in concentrating, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Cardiovascular disease
This medicine should be used with extreme caution in patients with a disease of the heart or the blood vessels due to the increased risk of worsening of the patient's condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Osteoporosis
This medicine should be used with extreme caution in patients with a history of osteoporosis due to the increased risk of worsening of the patient's condition. Close monitoring of bone mineral density is recommended for these patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Dose variations
The dose regimen of this medicine is likely to vary based on the gender of the patient and the condition being treated.
Missed Dose
If you miss a dose of this medicine, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose. Do not use extra medicine to make up for the missed dose. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Amitriptyline
Ondansetron
Disopyramide
Sotalol
Methadone
Azithromycin
Erythromycin
Amiodarone
Quinidine
Chlorpromazine
Salbutamol
Moxifloxacin
Propafenone
Disease interactions
Urinary tract obstruction
This medicine should be used with extreme caution in patients suffering from a partial obstruction of the urinary tract since it may worsen the patient's condition. Close monitoring of the patient's condition is recommended in such cases. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases. Use is not recommended in patients suffering from a complete obstruction of the urinary tract.
Diabetes
This medicine should be used with caution in patients with diabetes due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Cardiovascular disease
This medicine should be used with caution in patients suffering from cardiovascular diseases such as hypertension, QT prolongation, congestive heart failure, etc. and patients predisposed to changes in heart rhythm due to the increased risk of worsening of the patient's condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient. Use of this medicine is not recommended if the increase in blood pressure is not controlled using appropriate medicines.
Osteoporosis
This medicine should be used with caution in patients suffering from osteoporosis due to the increased risk of worsening of the patient's condition. Frequent clinical monitoring of bone mineral density is advised, especially in case of prolonged usage of this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Administer this medicine exactly as prescribed by the doctor. It is advised to administer this medicine in the presence of your doctor or a trained healthcare professional at least until you are trained on the procedure. Do not use this medicine in larger or smaller quantities than recommended. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
This medicine works by altering the levels of certain specific hormones in the body.
Legal Status
Classification
Category
Gonadotropin releasing hormone (GnRH) agonists
Schedule
Schedule H
[Internet]. Medsafe.govt.nz. 2018 [cited 17 September 2018]. Available from:
[Internet]. Hpra.ie. 2018 [cited 17 September 2018]. Available from:
[Internet]. Medicines.org.uk. 2018 [cited 17 September 2018]. Available from:
Buserelin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 17 September 2018]. Available from:
Buserelin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 17 September 2018]. Available from:
Ibrahim ZH e. Use of buserelin in an IVF programme for pituitary-ovarian suppression prior to ovarian stimulation with exogenous gonadotrophins. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2018 [cited 17 September 2018]. Available from:
Information on this page was last updated on 18 Sep 2018
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.