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Amigatin Tablet

Manufactured byCRESCENT FORMULATIONS PVT LTD
ContainsGabapentin (300 mg) + Amitriptyline (10 mg)
Description

Amigatin Tablet is a combination medicine used for the treatment of neuropathic disorders like neuropathic pain, postherpetic neuralgia, etc. This medicine is not recommended for use in patients below 12 years of age.

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Side effects

Major & minor side effects for Amigatin Tablet

  • Dizziness
  • Uncontrolled eye movements
  • Agitation and anxiety
  • Restlessness
  • Hyperactivity
  • Unusual tiredness and weakness
  • Irritability
  • Blurred vision
  • Lower back pain
  • Increased appetite
  • Dry mouth
  • Headache
  • Nausea and Vomiting
  • Weakness in one side of the body
  • Slurred speech
  • Seizures
  • Decreased sexual urge
  • Unusual bleeding
  • Constipation or diarrhea
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Unexpected weight gain or loss
  • Chest pain and discomfort
  • Shortness of breath

Uses of Amigatin Tablet

What is it prescribed for?

  • Postherpetic Neuralgia
  • Neuropathic pain
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 2-3 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to gabapentin, amitriptyline or any other inactive ingredients present in the formulation.

Monoamine oxidase inhibitors

This medicine is not recommended for use in patients taking monoamine oxidase inhibitors (MAOI) due to the increased risk of serious and life-threatening side effects. A time gap of at least 14 days should be maintained between stopping therapy with MAOIs and starting therapy with this medicine.

Cisapride

This medicine is not recommended for use along with Cisapride due to an increased risk of side effects on heart and blood vessels.

Heart attack

This medicine is not recommended for use if the patient is recovering from a recent heart attack due to the increased risk of worsening the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Skin reactions

This medicine should be used with caution since it may increase the risk of serious skin reaction like Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Report any unusual symptoms to the doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypotension

Use of this medicine may increase the risk of fall in blood pressure, and hence, caution is advised. Regular monitoring of blood pressure is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver disease

This medicine should be used with caution in patients who are suffering from liver diseases due to the increased risk of adverse effects. Regular monitoring of the liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney disease

This medicine should be used with caution in patients who are suffering from kidney diseases due to the increased risk of adverse effects. Regular monitoring of the kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bipolar disorder

This medicine should be used with extreme caution in patients suffering from bipolar disorder due to the increased risk of worsening the patient's condition. Consult your doctor and report the incidence of bipolar depression or mania before receiving this medicine. An alternative treatment option should be considered in some cases based on the clinical condition.

Benign prostatic hyperplasia

This medicine should be used with caution if you have an enlarged prostate gland due to the increased risk of worsening the condition. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Withdrawal symptoms

Abrupt discontinuation of this medicine may increase the risk of adverse effects, especially if you have been using a high dose for a long duration. A gradual dose reduction is recommended to avoid these reactions. Do not stop the use of this medicine without consulting your doctor.

Other medicines

Amigatin Tablet may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Use in Children

This medicine is not recommended for use in patients below 12 years of age since the safety and efficacy of use are not clinically established.

Surgery

Use of this medicine is not recommended if you are planning to undergo a surgery in near future. Consult your doctor in this regard so that it can be discontinued properly.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Suicidal tendencies

This medicine should be used with caution due to the increased risk of suicidal tendencies. This risk is especially higher in young patients. Patients should be closely monitored for any change in mood or behavior. Report any such incidence to the doctor so that counseling and monitoring of progress can be performed at regular intervals. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Clozapine

Duloxetine

Fluoxetine

Linezolid

Ondansetron

Buprenorphine

Selegeline

Phenylephrine

Disease interactions

Kidney Disease

This medicine should be used with caution in patients who are suffering from kidney diseases due to the increased risk of adverse effects. Regular monitoring of the kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Heart Disease

This medicine should be used with caution in patients suffering from heart disease like heart failure, stroke, heart block etc due to the increased risk of adverse effects. A fall in blood pressure, changes in the pulse, dizziness and other associated complications should be reported to the doctor on priority. It is advised to not take this medicine if the patient has recently suffered a heart attack. An alternative treatment option should be considered in some cases based on the clinical condition.

Pheochromocytoma

This medicine should be administered with extreme caution in patients suffering from Pheochromocytoma, the risk of severe to fatal change in blood pressure is very high. You may require a dose adjustment and more frequent clinical monitoring to safely use this medicine. An alternative treatment option should be considered in some cases based on the clinical condition.

Seizure disorders

This medicine should be used with caution in patients who are suffering from seizures due to the increased risk of worsening of the condition. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes

This medicine should be used with caution if you have diabetes as the risk of changes in blood sugar levels are very high. You should get your blood sugar levels checked more frequently while using this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Glaucoma

This medicine should be used with caution if you have glaucoma. Use of this medicine can worsen the symptoms of both closed and open-angle glaucoma. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food. Follow all the labeled instructions while taking this medicine. Ensure that the right quantity of medicine is consumed for the prescribed duration only. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Gabapentin works by reducing the hyperexcitability of the brain cells and also relieves the pain by altering the way the body senses the pain. Amitriptyline works by increasing the levels of certain chemicals in the brain.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Gamma-aminobutyric acid analogs, Tricyclic antidepressants

Schedule

Schedule H

[Internet]. Larenon.com. 2018 [cited 12 October 2018]. Available from:

http://www.larenon.com/wp-content/uploads/2015/08/laregab_n_at_n_ls2.pdf

Gabapentin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 9 May 2017]. Available from:

https://www.drugbank.ca/drugs/DB00996

DailyMed - amitriptyline hydrochloride tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 21 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd
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Information on this page was last updated on 5 Mar 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.