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Amifru Plus Tablet
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Amifru Plus Tablet

Manufactured byTORRENT PHARMACEUTICALS LTD
ContainsTorsemide (10 mg) + Amiloride (5 mg)
Description
Amifru Plus Tablet is a combination medicine used for the treatment of hypertension and edema associated with congestive heart failure. This medicine is not recommended for use in patients below 18 years of age.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Amifru Plus Tablet

  • Diarrhea
  • Headache
  • Nausea and vomiting
  • Loss of appetite
  • Abdominal pain
  • Dizziness
  • Dry mouth
  • Weakness
  • Difficulty in breathing
  • Numbness or tingling in the hands, feet, or lips
  • Nervousness

Uses of Amifru Plus Tablet

What is it prescribed for?

  • Hypertension
  • Edema Associated with Congestive Heart Failure
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of hypotension and adverse effects such as dizziness, fainting, lightheadedness, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is this a habit forming medicine?
    No-habit forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to amiloride, torsemide, or any other inactive ingredients present in the formulation.

Anuria

This medicine is not recommended for use in patients with anuria (a condition where the kidney is unable to produce urine) due to the increased risk of worsening of the patient's condition.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (BUN > 30 mg/dL, Scr > 1.5 mg/dL) due to the increased risk of worsening of the patient's condition.

Hyperkalemia

This medicine is not recommended for use in patients with hyperkalemia (elevated blood levels of potassium in the body) due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Liver Disease

This medicine should be used with extreme caution in patient's suffering from liver diseases due to an increase in the risk of serious adverse effects. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients with a known history of kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Potassium supplements

Use of this medicine will increase the potassium levels in the blood. Therefore, it is advised to avoid potassium-rich foods (potatoes, banana) and medicines that can increase potassium levels (ACE inhibitors and potassium supplements while receiving this medicine.

Driving or operating machines

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Volume and electrolyte depletion

Use of this medicine may alter the blood volume levels and electrolyte levels. Close monitoring of blood pressure and electrolyte levels is necessary while taking this medicine. Report any symptoms such as weakness, lethargy, muscle pain, drowsiness, dizziness, irregular heartbeat, etc. to the doctor immediately.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of hypotension and adverse effects such as dizziness, fainting, lightheadedness, etc. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Nonsteroidal anti-inflammatory drugs

Potassium Chloride

ACE inhibitors

Lithium

Disease interactions

Diabetes Mellitus

This medicine should be used with caution in patients with diabetes due to the increased risk of altered blood glucose levels and hyperkalemia, which may result in life-threatening cardiac arrhythmias. Close monitoring of blood glucose levels, serum potassium levels, and kidney function tests are necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Electrolyte imbalance

This medicine is not recommended for use in patients with electrolytes imbalance due to the increased risk of worsening of the patient's condition. Electrolytes levels should be corrected before starting the treatment with this medicine. Monitoring of potassium, sodium and other electrolytes levels is necessary while receiving this medicine. An alternative treatment option should be considered in some cases based on the clinical condition.

Liver Disease

This medicine should be used with extreme caution in patient's suffering from liver diseases due to an increase in the risk of serious adverse effects. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney Disease

This medicine should be used with extreme caution in patient's suffering from acute or progressive renal insufficiency, or diabetic nephropathy due to the increased risk of hyperkalemia, which may result in life-threatening cardiac arrhythmias. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperuricemia

This medicine should be used with caution in patients with hyperuricemia since this medicine decreases the uric acid excretion which results in serious side effects. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.
Food interactions
It is recommended to avoid a high potassium diet during treatment with this medicine due to the increased risk of serious adverse effects. Your doctor/dietitian will suggest appropriate changes in your diet to avoid high intake of potassium.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine exactly as advised by your doctor. Do not take in larger amounts than prescribed. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary while taking this medicine. Report any adverse effects to the doctor on priority. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by increasing the excretion of water and sodium and reduces blood pressure.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Diuretics

Schedule

Schedule H

Torsemide Oral: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 23 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a601212.html

[Internet]. 2019 [cited 28 March 2019]. Available from:

https://www.medicines.org.uk/emc/medicine/22290

[Internet]. Medicines.org.uk. 2019 [cited 28 March 2019]. Available from:

https://www.medicines.org.uk/emc/files/pil.6020.pdf

Amiloride [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 4 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/amiloride#

Amiloride - DrugBank [Internet]. Drugbank.ca. 2018 [cited 4 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00594
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Information on this page was last updated on 28 May 2019

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