Amifostine

Description

Amifostine is used to protect the kidneys from the side effects associated with the use of chemotherapeutic agents and radiation therapy. It is also be used for the treatment of abnormal dryness of the mouth (xerostomia) in patients undergoing radiotherapy for head and neck cancer.

Side effects

Major & minor side effects for Amifostine

  • Nausea and Vomiting
  • Low blood pressure
  • Lightheadedness, dizziness, or fainting
  • Blurred vision
  • Sweating
  • Skin rash
  • Chest tightness
  • Difficulty in breathing
  • Headache

Uses of Amifostine

What is it prescribed for?

  • Renal toxicity
  • Xerostomia
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to Amifostine, aminothiol compounds, or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
General warnings

Adequate hydration

Patients are advised to ensure adequate hydration due to the increased risk of dehydration. Drink an adequate amount of water or liquids to maintain hydration.

Cutaneous reactions

This medicine may cause serious cutaneous reactions such as skin rash, lesions, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema, etc. in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hypocalcemia

This medicine may lower the blood calcium levels and hence should be used with extreme caution in patients with hypocalcemia (decreased calcium levels in the blood) due to the risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Use in children

The safety and efficacy of this medicine have not been clinically established in children below 18 years of age.

Driving or operating machinery

Use of this medicine may cause dizziness, fatigue, and blurring of vision. Hence, it is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. However, it is advised to contact the doctor if a dose of Amifostine is missed and schedule the dose as soon as possible.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Antihypertensives

Etelcalcetide

Disease interactions

Hypotension

This medicine is not recommended for use in patients who are hypotensive (low blood pressure) or dehydrated, or who are unable to stop antihypertensive therapy 24 hours prior to Amifostine therapy due to the risk of worsening of the patient's condition. Close monitoring of blood pressure levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
The medicine binds to the reactive metabolites of cisplatin or alkylating agents and removes the free radicals and protects the kidney from harmful effects. It also increases secretion by the salivary glands.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antineoplastic detoxifying agents

Schedule

Schedule H

Amifostine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 14 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/amifostine

Amifostine Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 14 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a696014.html

[Internet]. Accessdata.fda.gov. 2018 [cited 14 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020221s024lbl.pdf

Safety Information | Ethyol (amifostine) for Injection [Internet]. Ethyol.com. 2018 [cited 14 December 2018]. Available from:

http://www.ethyol.com/usa/safety-information/

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Information on this page was last updated on 8 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.