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Ambrisentan

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Description

Ambrisentan is an antihypertensive drug specifically used in the treatment of pulmonary arterial hypertension (PAH) (WHO class 1), a condition characterized by high blood pressure in the vessels carrying blood from the heart to the lungs. It is also used in combination with tadalafil to reduce progression of the disease and improve exercise tolerance. Female patients are advised to undergo a pregnancy test to exclude pregnancy before beginning treatment with this medicine.

Uses of Ambrisentan

What is it prescribed for?

  • Pulmonary arterial hypertension

    Ambrisentan is used in the treatment of pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure inside the blood vessels carrying blood from the heart to the lungs.

Side effects

Major & minor side effects for Ambrisentan

  • Hypersensitivitysevererare
  • Unexpected weight gain or losssevere
  • Tingling of hands or feetsevere
  • Coughsevere
  • Rapid or irregular heartbeatsevere
  • Trouble breathingsevere
  • Runny nose and sore throatsevere
  • Headachesevere
SEVERE
Contact your doctor immediately if any of these symptoms are experienced on a regular basis.
RARE
Observed in a small fraction of population.
This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Highlights

Commonly asked questions for Ambrisentan

Onset of action

The amount of time required for this medicine to show its action is not clinically established.

Duration of effect

The amount of time for which this medicine remains active in the body is not clinically established.

Safe with alcohol?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?

No habit forming tendencies were reported.

Usage in pregnancy?

This medicine is not recommended for use in pregnant women.

Usage while breast-feeding?

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

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When not to use?

Contraindications of Ambrisentan

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to ambrisentan or any other components present along with it.

  • Pregnancy

    This medicine is not recommended for use in pregnant women.

  • Idiopathic pulmonary fibrosis

    This medicine is not recommended for use in patients with idiopathic pulmonary fibrosis (IPF) with or without pulmonary arterial hypertension due to the increased risk of worsening of the patient's condition.

Dosage

  • Missed Dose

    Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

  • Description

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Instructions

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Disease interactions

  • Disease

    Information not available.

Food interactions

  • Information not available.

Lab interactions

  • Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

General Instructions

Take Ambrisentan as instructed by the doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.

Warnings

Warnings for special population

  • Pregnancy

    - This medicine is not recommended for use in pregnant women.

  • Breast-feeding

    - This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

General warnings

  • Use in pediatrics

    - This medicine is not recommended for use in children and adolescents.

  • Infertility

    - This medicine may reduce the sperm count in males. Discuss with your doctor all the risks and benefits before beginning treatment with this medicine.

  • Effective contraception

    - Since Ambrisentan may cause serious fetal harm, use of highly effective contraceptive methods is advised for females of reproductive potential while on treatment with this medicine and one month after stopping the therapy to avoid pregnancy.

  • Elevated liver enzymes

    - Therapy with this medicine may raise the AST and ALT levels. It is advised to discontinue the therapy if the AST or ALT levels are greater than 5 times the Upper Limit of Normal (ULN).

  • Fluid overload

    - This medicine may cause an increased risk of edema in ankles and feet due to fluid retention. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • May cause sleepiness

How it works

Ambrisentan works by blocking the actions of endothelin 1, a natural substance responsible for pulmonary arterial hypertension.

Legal Status

Approved
Approved
Approved
Approved

Classification

Category
Endothelin receptor antagonist
Schedule
N/A

References

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Information on this page was last updated on 9 Sep 2017

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Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.