Aliskiren

Description

Aliskiren is used alone or in combination with other medicines for the treatment of high blood pressure in adults. Patients are advised to follow a strict exercise and diet regimen along with this medicine to get the best possible effect.

Side effects

Major & minor side effects for Aliskiren

  • Diarrhea
  • Cough
  • Rash
  • Increase in uric acid
  • Headache
  • Hypotension
  • Stomach pain
  • Back pain
  • Nausea and Vomiting

Uses of Aliskiren

What is it prescribed for?

  • Hypertension
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to aliskiren or any other components present along with it.

Angiotensin converting enzyme inhibitors and Angiotensin receptor blockers

Aliskiren is not recommended for use along with Angiotensin converting enzyme inhibitors or Angiotensin receptor blockers in patients with diabetes mellitus due to the increased risk of severe side effects. These side effects may include severe hypotension, increased potassium levels, and worsening of renal disorders.

Angioedema

Aliskiren is not recommended for use in patients with a known history of angioedema associated with Aliskiren or hereditary angioedema due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hypotension

This medicine may cause hypotension in patients with volume and salt depletion. Regular monitoring of blood pressure and electrolytes levels is recommended during treatment with this medicine. Appropriate dose adjustments may be necessary based on the clinical condition.

Hyperkalemia

This medicine may significantly increase the potassium levels in the blood (hyperkalemia). This may cause serious adverse effects. Report any unusual symptoms to the doctor immediately. Close monitoring of potassium levels and kidney function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Renal disease

This medicine should be used with caution in patients with mild to moderate renal impairment due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition. This medicine is not recommended for use in patients with severe renal impairment.

Pediatric use

The safety and efficacy of this medicine have not been clinically established in children and adolescents.

Missed Dose

If a dose of Aliskiren is missed, take the missed dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose. Do not double the dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Itraconazole

Cyclosporine

Nonsteroidal anti-inflammatory medicines

Furosemide

Disease interactions

Disease

Information not available.
Food interactions
Avoid drinking grapefruit, orange, or apple juice and eating a high-fat meal during treatment with this medicine since these foods may decrease the absorption and effects of this medicine. Your doctor/dietitian may suggest appropriate changes in your diet to avoid this interaction.
Lab interactions
Information not available.
Take Aliskiren with or without food. Do not take in larger or smaller amounts than advised. Inform the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Aliskiren works by relaxing the blood vessels. This allows the blood to flow smoothly and decreases the blood pressure.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Renin inhibitors

Schedule

N/A

Aliskiren - DrugBank [Internet]. Drugbank.ca. 2017 [cited 29 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB09026

Aliskiren: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 29 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a607039.html

DailyMed - Tekturna - Aliskiren hemifumarate tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 29 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3dd61fa5-1620-4ebf-bbdb-ede29b92fce2

[Internet]. 2017 [cited 12 September 2017]. Available from:

https://www.medicines.org.uk/emcmobile/PIL.20050.latest.pdf

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Information on this page was last updated on 13 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.