Alfacalcidol

Description

Alfacalcidol is used as a supplement to treat deficiency of Vitamin D associated with conditions such as hypocalcemia (decreased blood calcium levels), rickets (weakening of bones), etc. It is also used to treat calcium metabolism disturbances (deficiency and elevation of calcium levels in the bones and/or blood) caused due to diseases of the kidneys and the parathyroid gland.

Side effects

Major & minor side effects for Alfacalcidol

  • Headache
  • Drowsiness
  • Irregular heart beat
  • Constipation
  • Nausea and Vomiting
  • Fever
  • Increased thirst
  • Skin rash and itching
  • Bone and joint pain
  • Muscle pain and weakness
  • Increased calcium levels
  • Decreased libido

Uses of Alfacalcidol

What is it prescribed for?

  • Hypocalcemia
  • Hypophosphatemic vitamin D-resistant rickets and osteomalacia
  • Renal Osteodystrophy
  • Osteomalacia and Rickets
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken for this medicine to show its effect is subject to variations based on the route of administration. Peak concentrations are achieved after 12 hours of oral administration and 4 hours of intravenous administration (injection).
  • Duration of effect
    This effect of this medicine lasts for an average duration of 2 to 7 days.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine. If the medicine is used, the infant should be monitored closely for any undesirable side effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to alfacalcidol or any other inactive ingredients present along with it.

Hypercalcemia

This medicine is not recommended for use in patients with elevated levels of calcium in the blood due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking/receiving this medicine. If the medicine is used, the infant should be monitored closely for any undesirable side effects.
General warnings

Hypercalcemia

This medicine is not recommended for use in patients with elevated levels of calcium in the blood (hypercalcemia). Blood calcium levels should be checked before beginning therapy with this medicine. Close monitoring of blood calcium levels is recommended during treatment with this medicine as well. Appropriate corrective measures and/or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Hypervitaminosis D

This medicine is not recommended for use in patients with high levels of Vitamin D in the body. Appropriate corrective measures, dose adjustments, and/or replacement with a suitable alternative should be considered based on the clinical condition of the patient.

Other Vitamin D products

This medicine is not recommended for use in patients receiving other supplements or drugs containing vitamin D as an ingredient due to the increased risk of serious adverse effects. It is advised that you report to the doctor all your current medicines including any herbs and supplements before beginning therapy with this medicine.

Cardiovascular diseases

This medicine should be used with caution in patients suffering from cardiovascular diseases due to the increased risk of worsening of the patients' condition. This risk is especially higher if the medicine is used for a prolonged period of time. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Oral forms: Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose. Injections: Since this medicine is usually administered in the clinical/hospital setting by a qualified healthcare professional, the likelihood of a missed dose is very low. If you miss an appointment for receiving this medicine, contact your doctor immediately for further instructions.

Overdose

Discontinue the use of this medicine and consult your doctor immediately if an overdose is suspected. Consumption of Vitamin D rich food or supplements along with this medicine may also cause an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Hydrochlorothiazide

Cholestyramine

Magnesium/Aluminum containing medicines

Laxatives

Digoxin

Phenytoin

Carbamazepine

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Oral forms: Use this medicine exactly as prescribed by the doctor. Do not use in larger or smaller amounts than advised. Injections: This medicine is usually administered in the hospital/clinical setting by a qualified healthcare professional. Report any undesirable side effects to the doctor immediately. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by stimulating the absorption of calcium and phosphorus from the intestines. It also promotes reabsorption of calcium from the bones and the kidneys.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Vitamins

Schedule

OTC

Alfacalcidol [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 31 July 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/alfacalcidol#section=Top

Alfacalcidol - an overview | ScienceDirect Topics [Internet]. Sciencedirect.com. 2018 [cited 31 July 2018]. Available from:

https://www.sciencedirect.com/topics/neuroscience/alfacalcidol

Loredana Cavalli M. Biological effects of various regimes of 25-hydroxyvitamin D3 (calcidiol) administration on bone mineral metabolism in postmenopausal women [Internet]. PubMed Central (PMC). 2018 [cited 31 July 2018]. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781231/

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Information on this page was last updated on 2 Aug 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.