Activated Protein C

Description

Activated Protein C is a recombinant form of human activated protein C which is used for the prevention and treatment of blood clots and coagulation disorders. It is also used for reducing the death rates in patients suffering from severe blood infections and associated organ dysfunction. This medicine is not recommended for use in patients below 18 years of age.

Side effects

Major & minor side effects for Activated Protein C

  • Bleeding
  • Injection site reations (pain,swelling)
  • Rash
  • Low blood pressure (hypotension)
  • Wheezing
  • Decreased urine output

Uses of Activated Protein C

What is it prescribed for?

  • Sepsis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to activated protein C, or any other inactive ingredients present in the formulation.

Active internal bleeding

This medicine is not recommended for use in patients who have active internal bleeding due to the increased risk of worsening of the patient's condition.

Intracranial Surgery/Head Trauma

This medicine is not recommended for use in patients who have had a recent intracranial surgery or severe head trauma due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.
General warnings

Severe allergic reactions

Use of this medicine may cause severe allergic reactions in some people. Discontinue the use of this medicine immediately if any allergic reactions occur. Injection site reactions may also occur with this medicine.

Risk of bleeding

Use of this medicine may increase the risk of bleeding, especially when administered along with other anticoagulant medicines. Close clinical monitoring for any signs and symptoms of bleeding is recommended. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver disease due to the increased risk of adverse effects. Regular monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Other medicines

Activated Protein C may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Enoxaparin

Alteplase

Apixaban

Warfarin

Diclofenac

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine. Close monitoring of the patient is recommended during the treatment and inform your doctor immediately if you develop any signs and symptoms of an allergy and/or bleeding.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by inhibiting certain factors which are responsible for clotting.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Miscellaneous coagulation modifiers

Schedule

Schedule H

Tazbir J. Sepsis and the Role of Activated Protein C [Internet]. Ccn.aacnjournals.org. 2019 [cited 7 January 2019]. Available from:

http://ccn.aacnjournals.org/content/24/6/40.full

[Internet]. Ema.europa.eu. 2019 [cited 7 January 2019]. Available from:

https://www.ema.europa.eu/documents/product-information/xigris-epar-product-information_en.pdf

[Internet]. Accessdata.fda.gov. 2019 [cited 7 January 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/125029s065lbl.pdf

Drotrecogin alfa - DrugBank [Internet]. Drugbank.ca. 2019 [cited 7 January 2019]. Available from:

https://www.drugbank.ca/drugs/DB00055

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Information on this page was last updated on 12 Sep 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.