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Actifed DM Cough Syrup
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Actifed DM Cough Syrup

Manufactured byGLAXOSMITHKLINE PHARMACEUTICALS LTD
ContainsTriprolidine (1.25 mg/5 ml) + Dextromethorphan (10 mg/5 ml)
Description
Actifed DM Cough Syrup is a combination medicine which is used to relieve dry and irritating cough associated with respiratory tract disorders. This medicine is not recommended for use in children below 2 years of age.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Actifed DM Cough Syrup

  • Confusion
  • Constipation
  • Drowsiness
  • Nausea or Vomiting
  • Stomach pain
  • Headache
  • Dizziness
  • Blurred vision
  • Heartburn

Uses of Actifed DM Cough Syrup

What is it prescribed for?

  • Dry Cough
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 15 to 30 minutes of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of up to 6 to 8 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, confusion, depression, impaired judgment, fainting, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the benefits and risks should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to triprolidine, dextromethorphan, or any other inactive ingredients present along with the formulation.

Respiratory depression

This medicine is not recommended for use in patients with or at risk of developing respiratory depression, in the absence of resuscitative equipment, due to the increased risk of worsening of the patient's condition.

Sedatives or tranquilizers

This medicine is not recommended for use in patients undergoing treatment with sedatives or tranquilizers due to the increased risk of serious adverse effects.

Monoamine oxidase inhibitors (MAOI)

Use of this medicine is not recommended if the patient has taken MAO inhibitors like selegiline or rasagiline within the last 14 days. Their combination may increase the risk of severe adverse effects like drowsiness and blurred vision.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the benefits and risks should be discussed with the doctor before taking this medicine.
General warnings

Emphysema

This medicine should be used with caution in patients with emphysema due to the increased risk of worsening of the patient's condition. Report all your medical conditions/diseases to the doctor before taking this medicine. An alternative treatment option may be necessary based on the clinical condition of the patient.

Chronic bronchitis

This medicine should be used with caution in patients with chronic bronchitis due to the increased risk of worsening of the patient's condition. Report all your medical conditions/diseases to the doctor before taking this medicine. An alternative treatment option may be necessary based on the clinical condition of the patient.

Other medicines

This medicine may interact with many other medicines and may cause significant side effects. Hence, it is advised that you report all your current medicines to the doctor, including any herbs and supplements, before beginning treatment with this medicine.

Liver and/or kidney impairment

Caution is advised while using this medicine in patients with liver/kidney diseases due to an increase in the risk of severe adverse effects in these patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

CNS depression

This medicine should be used with caution in patients with a known history of CNS disorders due to the increased risk of severe side effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Driving or operating heavy machinery

Use of this medicine may cause blurred vision, dizziness, drowsiness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Use in Children

This medicine is not recommended for use in patients below 2 years of age since the safety and efficacy of use are not clinically established. However, your doctor may prescribe this medicine if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any adverse effects.

Missed Dose

Take/Administer the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, confusion, depression, impaired judgment, fainting, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Amitriptyline

Citalopram

Escitalopram

Metoclopramide

Ondansetron

Alprazolam

Isocarboxazid

Perphenazine

Amantadine

Azatadine

Disease interactions

Psychiatric Conditions

This medicine should be used with caution in patients with psychiatric conditions due to an increased risk of confusion and hallucinations. An alternative treatment option should be considered based on the clinical condition of the patient.

Asthma/ COPD

This medicine should be used with caution in patients with a known history of asthma/COPD due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Renal Diseases

This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Cardiovascular disease

This medicine should be used with caution in patients with cardiovascular diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take/Administer this medicine as advised by your doctor. You may take this medicine with or without food. Do not take more than what is prescribed or share this medication with other people. Report any undesired side effects to the doctor. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Triprolidine works by blocking certain natural substances (histamines) responsible for causing an allergic reaction. Dextromethorphan blocks the signals from the brain that trigger cough reflex and thus it helps in suppressing the cough. Hence, this combination is better effective in treating cough.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Antitussives, Antihistamines, Respiratory agents

Schedule

Schedule H

[Internet]. India-pharma.gsk.com. 2019 [cited 20 May 2019]. Available from:

https://india-pharma.gsk.com/media/701003/actifed-dm-cough-syrup.pdf

Triprolidine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 19 October 2017]. Available from:

https://www.drugbank.ca/drugs/DB00427

DailyMed - Triprolidine hydrochloride liquid [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 19 October 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5c2fb4cc-c5a3-421c-91d4-c5bbe2189467

Dextromethorphan - DrugBank [Internet]. Drugbank.ca. 2017 [cited 11 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB00514
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Information on this page was last updated on 19 Jul 2019

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