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Aclasta 5 mg Infusion

Manufactured byNovartis India Ltd.
ContainsZoledronate
Description
Aclasta 5 mg Infusion is used to treat and prevent osteoporosis in postmenopausal women and also in men and women who are on corticosteroid therapy. This medicine brings down high levels of calcium in the blood that may be caused by some cancers. It is used to treat Paget's disease of bone, a condition in which the bones are weak, thin, deformed, and easily fractured. In cancer therapy, this medicine can be used to prevent or treat bone damage caused by cancer cells.

Side effects

Major & minor side effects for Aclasta 5 mg Infusion

  • Hypersensitivity
  • Redness or swelling of eyes
  • Abdominal and stomach pain
  • Nausea and vomiting
  • Heartburn
  • Difficulty with swallowing
  • Irregular heartbeat
  • Loss of appetite
  • Trouble sleeping
  • Pain at the injection site

Uses of Aclasta 5 mg Infusion

What is it prescribed for?

  • Osteolytic bone lesions of multiple myeloma
  • Osteolytic bone metastases of solid tumours
  • Hypercalcemia of malignancy
  • Paget's disease
  • Osteoporosis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action may vary based on the intended use.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body may vary based on the intended use.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known history of allergy to Zoledronate or any other inactive ingredients present in the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Severe bone, joint and/or muscle pain

This medicine may cause severe bone, joint, and/or muscle pain. Report any such symptoms to the doctor on priority. Your doctor may advise you to discontinue therapy based on your clinical condition.

Flu-like symptoms

This medicine may cause flu-like symptoms after the dose administration. Consult the doctor if the symptoms do not resolve within 14 days.

Thigh and hip bone fracture

The use of this medicine may increase the risk of a thigh and hip bone fracture. Care should be taken to avoid any falls or other trauma to reduce this risk.

Osteonecrosis of the jaw

This medicine may rarely cause osteonecrosis of the jaw in some patients. This risk is especially higher in patients undergoing invasive dental procedures. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Driving or operating machinery

This medicine may cause dizziness, weakness, or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during or immediately after treatment with this medicine.

Missed Dose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the clinical setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Deferasirox

Immunosuppressants

Etelcalcetide

Methotrexate

Torsemide

Disease interactions

Hypocalcemia

This medicine is not recommended for treating osteoporosis in patients with decreased calcium levels (hypocalcemia). Calcium and vitamin D levels should be checked before starting therapy with this medicine. It is also important to continue the appropriate supplementation of calcium and vitamin D during treatment with this medicine.

Kidney impairment

This medicine should be used with extreme caution in patients with kidney impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Asthma

This medicine should be used with caution in patients with asthma due to the increased risk of worsening of the patient's condition. Close monitoring of such patients for any adverse effects is necessary during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor and do not miss an appointment to receive this medicine. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine increases bone thickness and reduces the chances of bone breakage.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Bisphosphonates

Schedule

Schedule H

Aclasta 5 mg solution for infusion - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2020 [cited 1 June 2020]. Available from:

https://www.medicines.org.uk/emc/product/210/smpc

Zoledronic acid - DrugBank [Internet]. Drugbank.ca. 2017 [cited 9 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00399

Zoledronic Acid 5 mg/100ml solution for infusion - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2020 [cited 17 April 2020]. Available from:

https://www.medicines.org.uk/emc/product/7203/smpc

Zoledronic acid [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 17 April 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/68740

DailyMed - Zoledronic Acid injection, solution, concentrate [Internet]. Dailymed.nlm.nih.gov. 2020 [cited 17 April 2020]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ac7ff1eb-6e73-4cc8-9114-c5a4483ad4c3
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Information on this page was last updated on 11 Jun 2020

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