Acitretin

Description

Acitretin is a retinoid used for the treatment of severe psoriasis in adult patients only. This medicine is not recommended for use in pregnant women.

Side effects

Major & minor side effects for Acitretin

  • Back pain
  • Headache
  • Change in taste
  • Nausea
  • Redness of skin
  • Trouble sleeping
  • Redness or swelling of eyes

Uses of Acitretin

What is it prescribed for?

  • Psoriasis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe suitable alternatives based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women. Your doctor may prescribe suitable alternatives based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to acitretin, any other retinoids, or any other inactive ingredients present along with this medicine.

Severe renal impairment

This medicine is not recommended for use in patients with a known history of severe kidney function impairment due to the increased risk of worsening of the patient's condition.

Severe Hepatic impairment

This medicine is not recommended for use in patients with a known history of severe liver function impairment due to the increased risk of worsening of the patient's condition.

Tetracyclines

This medicine is not recommended for use in patients receiving tetracyclines due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe suitable alternatives based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women. Your doctor may prescribe suitable alternatives based on your clinical condition.
General warnings

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Skeletal abnormalities

This medicine should be used with caution in patients suffering from vertebral/skeletal abnormalities due to the increased risk of worsening of the patient's condition. Prolonged use of this medicine may increase the risk of hyperostosis (excessive bone growth). Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Eye disorders

This medicine should be used with caution due to the increased risk of side effects such as dry eyes, eye irritation, eye swelling, blurred vision, etc. This risk is especially higher in patients suffering from pre-existing eye disorders. Report any unusual eye symptoms to the doctor immediately. Close monitoring of eye function with eye exams, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Driving or Operating machinery

Use of this medicine may cause symptoms such as blurred vision, dizziness, drowsiness, night blindness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Use in pediatrics

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Contraception and Pregnancy

Female patients of child-bearing potential are advised to use 2 effective forms of birth control beginning at least 1 month prior to starting treatment with this medicine, during the treatment, and for at least 3 years after stopping treatment with this medicine. It is important that you discuss effective long-term as well as emergency contraceptive measures with your doctor before beginning therapy with this medicine. If you do become pregnant during treatment with this medicine or within 3 years of stopping treatment with this medicine, contact your doctor immediately to discuss the possible effects on the unborn baby.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects.
Interaction with Medicine

Leflunomide

Chlorpropamide

Bexarotene

Glimepiride

Doxycycline

Vitamin A

Disease interactions

Hyperlipidemia

This medicine should be used with extreme caution in patients suffering from hyperlipidemia due to the increased risk of worsening of the patient's condition. Regular monitoring of blood lipid levels is necessary to safely use this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Psychiatric disorders

This medicine should be used with extreme caution in patients suffering from psychiatric disorders such as depression, suicidal tendencies, etc. due to the increased risk of worsening of the patient's condition. Patients should be monitored closely for any change in mood or behavior during treatment with this medicine. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Diabetes Mellitus

This medicine should be used with caution in patients suffering from diabetes mellitus due to the increased risk of altered blood sugar levels. Regular monitoring of blood glucose levels is necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
It works on specific receptors in the skin and normalizes the growth cycle of skin cells.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Antipsoriatics

Schedule

Schedule H

Acitretin 10mg Capsules - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 25 July 2018]. Available from:

https://www.medicines.org.uk/emc/product/5265/smpc

Acitretin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 25 July 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a601010.html

[Internet]. Accessdata.fda.gov. 2018 [cited 25 July 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/019821s027lbl.pdf

[Internet]. Soriatane.com. 2018 [cited 25 July 2018]. Available from:

http://www.soriatane.com/

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Information on this page was last updated on 26 Jul 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.