Acenocoumarol

Description

Acenocoumarol is an anticoagulant or blood thinner which is used in the treatment and prevention of abnormal blood clots. This medicine does not dissolve the blood clot that has already formed but may prevent it from becoming larger and leading to more serious problems. Close monitoring of INR and prothrombin time is necessary during treatment with this medicine.

Side effects

Major & minor side effects for Acenocoumarol

  • Hypersensitivity
  • Bleeding
  • Loss of appetite
  • Nausea and vomiting
  • Liver injury
  • Alopecia
  • Dizziness
  • Headache
  • Blood in urine
  • Blurred vision

Uses of Acenocoumarol

What is it prescribed for?

  • Prevention and treatment of thromboembolism
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 24 to 30 hours of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 2 days.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women due to the increased risk of serious fetal harm.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If the medicine is used, close monitoring of the infant for any undesired side effects is necessary. Discuss all the risks and benefits with your doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to acenocoumarol or any other components present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of serious fetal harm.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. If the medicine is used, close monitoring of the infant for any undesired side effects is necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
General warnings

Hepatic impairment

Caution is advised while using this medicine in patients with mild to moderate hepatic impairment due to the increased risk of severe adverse effects. Acenocoumarol is not recommended for use in patients with severe hepatic impairment.

Use in pediatrics

This medicine should be used with extreme caution in children and adolescents with close monitoring of PT/INR due to the increased risk of severe adverse effects. Appropriate dose adjustments should be done based on the clinical condition.

Geriatric use

Initiate Acenocoumarol therapy with lower doses in patients above 65 years of age due to the increased risk of adverse effects.

Surgery

Close monitoring of coagulation status is warranted while a patient receiving this medicine undergoes surgical procedures or tooth extraction due to the increased risk of excessive bleeding. Appropriate corrective measures and dose adjustments may be required based on the clinical condition.

Intramuscular injections

Intramuscular injections may cause hematomas in patients receiving this medicine and hence they are not recommended for use during treatment with Acenocoumarol.

Renal Impairment

Caution is advised while using this medicine in patients with mild to moderate renal impairment due to the increased risk of severe adverse effects. Acenocoumarol is not recommended for use in patients with severe renal impairment.

Missed Dose

Take the missed dose as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose. In emergency situations of severe hemorrhage, clotting factors can be returned to normal by administering fresh whole blood or fresh frozen plasma, complex concentrate or recombinant factor VIIa supplemented with vitamin K1.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Carbamazepine

Phenytoin

Rifampicin

Antacids

Heparin

Proton pump inhibitors

Protease inhibiors

Statin agents

Disease interactions

Disease

Information not available.
Food interactions
Drinking cranberry juice or capsules or concentrates containing cranberry extracts may increase the risk of bleeding in patients receiving Acenocoumarol. Hence, consumption of such products is not recommended during treatment with this medicine.
Lab interactions
Information not available.
Take Acenocoumarol with or without food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Acenocoumarol blocks the actions of vitamin K, a natural substance essential for the formation of a blood clot.
Legal Status

Approved

Unknown

Approved

Unknown

Classification

Category

Vitamin K antagonists, Anticoagulants

Schedule

N/A

[Internet]. 2017 [cited 31 August 2017]. Available from:

http://www.japi.org/february_2016/23_dc_acenocoumarol_a_review.pdf

[Internet]. 2017 [cited 31 August 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/31675

[Internet]. 2017 [cited 31 August 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.31673.latest.pdf

Acenocoumarol - DrugBank [Internet]. Drugbank.ca. 2017 [cited 31 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB01418

Acenocoumarol [Internet]. Snomedbrowser.com. 2017 [cited 31 August 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/387457003

TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 31 August 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~sx7Sd0:4

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Information on this page was last updated on 19 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.