Aceclofenac

Description

Aceclofenac is a non-steroidal anti-inflammatory medicine used to reduce pain from various conditions. It provides effective relief from pain, stiffness, and swelling due to ankylosing spondylitis and arthritis namely, osteoarthritis and rheumatoid arthritis. It is also used to provide relief from headaches, toothaches, backaches, menstrual pain, sprains, and strains. Aceclofenac works by preventing the release of a chemical substance that causes pain and swelling in the body. Common side effects of Aceclofenac are nausea, vomiting, heartburn, stomach pain, loss of appetite, and diarrhoea. Do not use this medicine if you are previously allergic to it. Use it cautiously in individuals with liver and kidney problems. You can take Aceclofenac with food, milk, or an antacid to avoid stomach irritation. For the ease of remembering, take it at around the same time every day. Aceclofenac relieves pain and swelling due to arthritic conditions but does not cure it.

Side effects

Major & minor side effects for Aceclofenac

  • Stomach pain
  • Diarrhoea
  • Nausea and vomiting
  • Skin rash
  • Loss of appetite
  • Indigestion
  • Heartburn
  • Dizziness
  • Drowsiness
  • Constipation

Uses of Aceclofenac

What is it prescribed for?

  • Rheumatoid Arthritis
  • Osteoarthritis
  • Ankylosing Spondylitis
  • Mild to moderate pain
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Concerns

Commonly asked questions

  • Onset of action
    Aceclofenac provides relief from pain within 1.5 to 3 hours of administration.
  • Duration of effect
    The duration of action for aceclofenac is 12 to 16 hours. You may have to take your next dose if your pain continues.
  • Safe with alcohol?
    Consumption of alcohol is not recommended while treatment with Aceclofenac due to the risk of stomach bleeding.
  • Is it habit forming?
    No habit forming tendencies were reported for Aceclofenac.
  • Usage in pregnancy?
    Aceclofenac is not recommended for use during pregnancy especially in the third trimester (last 3 months) due to the risk of harmful effects on your baby. But in some cases, your doctor may prescribe this medicine during the first 6 months of pregnancy if the benefits outweigh the risks. All the risks and benefits should be discussed with your doctor before starting the medicine.
  • Usage while breast-feeding?
    Aceclofenac is not recommended for use in breastfeeding women. An alternate medicine may be preferred, especially while nursing a newborn or preterm infant. If required, it should only be used upon your doctor's recommendation.

Allergy

Avoid taking Aceclofenac if you are previously allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms of serious allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.

Asthma

Patients with asthma may experience allergic reactions while taking Aceclofenac. Hence it is not recommended for use in patients with asthma, especially those who had experienced allergic reactions with the use of non-steroidal anti-inflammatory medicines.

Gastrointestinal bleeding

Aceclofenac may cause stomach and intestinal bleeding and ulcers. Therefore it is not recommended for use in patients with gastrointestinal bleeding or perforation disorders since it may worsen the condition.
Warnings for special population

Pregnancy

Aceclofenac is not recommended for use during pregnancy especially in the third trimester (last 3 months) due to the risk of harmful effects on your baby. But in some cases, your doctor may prescribe this medicine during the first 6 months of pregnancy if the benefits outweigh the risks. All the risks and benefits should be discussed with your doctor before starting the medicine.

Breast-feeding

Aceclofenac is not recommended for use in breastfeeding women. An alternate medicine may be preferred, especially while nursing a newborn or preterm infant. If required, it should only be used upon your doctor's recommendation.
General warnings

Skin rash

Aceclofenac may cause serious skin allergies without any warnings. These events may be fatal in rare cases. Signs and symptoms like rashes, hives, fever, or other allergic symptoms should be reported to the doctor immediately. The treatment should be discontinued if these symptoms appear.

Heart surgery

Do not use Aceclofenac for relieving pain after heart surgery.

Bleeding disorders

Aceclofenac may prolong the blood clotting time and therefore increase the risk of bleeding. Use it cautiously in patients with bleeding or clotting defects such as haemophilia, vitamin K deficiency, and hypoprothrombinemia.

Driving or operating machinery

Aceclofenac may cause sleepiness, blurred vision or dizziness in some patients. Hence it is advised not to drive vehicles and operate heavy machinery after taking this medicine.

Impaired liver function

Patients with liver diseases should ask their pharmacist/doctor how Aceclofenac may affect their liver. Aceclofenac conversion to its active form may be reduced in patients with impaired liver function, which may lead to liver failure. A dosage reduction may be required in some patients.

Missed Dose

Oral forms: Try not to skip the dose of aceclofenac. If it's time for the next dose, do not double the dose. Injection: Aceclofenac is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Oral forms: Seek emergency medical attention or contact the doctor in case of overdose. Injection: Since aceclofenac is administered in the hospital or clinical setting by a qualified healthcare professional, the chances of an overdose are very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while treatment with Aceclofenac due to the risk of stomach bleeding.
Interaction with Medicine

Corticosteroids

Antihypertensives

Digoxin

Lithium

Disease interactions

Gastro-Intestinal toxicity

Long term use of Aceclofenac can cause damage to the stomach and intestine. Serious conditions like bleeding, ulceration, and perforation of the stomach or intestinal wall can occur. Any symptom indicating ulceration and bleeding like chronic indigestion, the appearance of coffee coloured dry blood in stools or vomiting of blood should be reported immediately.

Impaired kidney function

Prolonged use of high doses of Aceclofenac may cause kidney problems, such as painful urination and protein or blood in the urine. Hence this medicine should be used cautiously in kidney impaired patients. Close monitoring of kidney function is necessary while receiving this medicine.

Heart Disease

Long-term use of Aceclofenac may increase the risk of a heart attack in patients with pre-existing heart conditions or heart failure. It is not used for treating pain after coronary bypass surgery.
Food interactions
Information not available.
Lab interactions
Information not available.
Oral forms: Take aceclofenac tablets and capsules and with or after food. Never take more than the prescribed dose. Take this medicine at the same time every day. Injection: Aceclofenac injection should be administered by a qualified healthcare professional in a clinic or hospital.
Miscelleneous

To be taken after food

To be taken as instructed by doctor

May cause sleepiness

How it works
Aceclofenac stops the release of a chemical called prostaglandins, that increase pain and swelling. Thus, this medicine provides relief from your aches and makes you feel better.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Nonsteroidal anti-inflammatory agents

Schedule

Schedule H

Medicines.org.uk. 2021. Aceclofenac 100 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 2 February 2021].

https://www.medicines.org.uk/emc/medicine/32903>

Dailymed.nlm.nih.gov. 2021. DailyMed - CLANZA CR- aceclofenac tablet, film coated. [online] Available at: < [Accessed 2 February 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8a023942-01e8-4849-aa3c-1a640ffc7fd3>

Mcs.open.ac.uk. 2021. Patient Information Leaflet. [online] Available at: < [Accessed 2 February 2021].

http://mcs.open.ac.uk/nlg/old_projects/pills/corpus/PIL/data/BristolMyers_Squibb/Preservex_Tablets/Preservex_Tablets.html>

Drugbank.ca. 2021. Aceclofenac | DrugBank Online. [online] Available at: < [Accessed 2 February 2021].

https://www.drugbank.ca/drugs/DB06736>

Pubchem.ncbi.nlm.nih.gov. 2021. Aceclofenac. [online] Available at: < [Accessed 2 February 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Aceclofenac>

Aceclofenac Injection Manufacturer & Supplier India | Buy Online. [online] Available at: < [Accessed 2 February 2021].

https://wellonapharma.com/product/finished/aceclofenac-injection>

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Information on this page was last updated on 1 Mar 2021

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.