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Abec-L Tablet
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Abec-L Tablet

Manufactured byEMCURE PHARMACEUTICALS LTD
ContainsAbacavir (600 mg) + Lamivudine (300 mg)
Description
Abec-L Tablet is a combination of Abacavir and Lamivudine. It is an antiviral medicine used for the treatment of human immunodeficiency virus (HIV) infection (a condition that occurs when the virus attacks the immune system and interferes with your body's ability to fight infections or diseases). Abec-L Tablet will not cure HIV infection, but it will delay the progression of a chronic, potentially life-threatening condition known as acquired immunodeficiency syndrome (AIDS) and other HIV-related conditions. This medicine works by preventing the virus from multiplying. Abec-L Tablet shows some side effects like nausea, vomiting, stomach pain, diarrhoea, headache, confusion, dizziness, trouble sleeping, etc. Consult your doctor if they bother you for a longer time or worsen. Do not take this medicine if you are allergic to it. Abec-L Tablet may be taken with food or without food. Take it in the dose and duration prescribed by your doctor. Avoid taking more than the recommended dose. Take it every day at the same time to maintain a consistent level of this medicine in your blood. Do not discontinue this medication without consulting your doctor, as it may worsen your condition. Abec-L Tablet may not be suitable for everyone. It is not recommended for use in children weighing less than 25 kg. Inform your doctor if you have heart, liver, or kidney problems or any other health conditions. Also, inform your doctor about all your ongoing medications to avoid undesired effects. Abec-L Tablet is unsafe for use during pregnancy. Consult your doctor if you are breastfeeding. If you have an HIV infection, it is not recommended to breastfeed, as the Human immunodeficiency virus (HIV) may transfer to the baby through breastmilk.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Abec-L Tablet

  • Chills and fever
  • Headache
  • Fatigue
  • Loss of appetite
  • Depression
  • Stuffy nose
  • Muscle pain
  • Heartburn
  • Indigestion
  • Sore throat
  • Stomach pain
  • Skin rash
  • Unusual tiredness
  • Trouble sleeping
  • Buffalo hump
  • Nausea or Vomiting

Uses of Abec-L Tablet

What is it prescribed for?

  • HIV infection
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time required for Abec-L Tablet to show its effect is not clinically established.
  • How long do the effects of this medicine last?
    The time duration for which Abec-L Tablet remains active in your body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Abec-L Tablet due to the increased risk of side effects.
  • Is this a habit forming medicine?
    No habit-forming tendency has been reported for Abec-L Tablet.
  • Can this medicine be taken during pregnancy?
    Abec-L Tablet may be unsafe for use during pregnancy as animal studies indicate that it may harm the developing foetus. However, there are no human data available. Hence, consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Abec-L Tablet is not recommended for use while breastfeeding. Also, women with HIV infection are not recommended to breastfeed as the Human immunodeficiency virus (HIV) can be passed to the baby through breastmilk.

Allergy

Avoid taking Abec-L Tablet if you are allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Moderate to severe liver impairment

Abec-L Tablet is not recommended for use if you have moderate to severe liver problems, as this medicine may cause liver toxicity and further worsen your condition.

HLA-B*5701-positive

Abec-L Tablet is not recommended for use if you have screened positive for human leukocyte antigen HLA-B*5701 (a gene that plays an important part in the body's immune response to foreign particles). Being positive indicates you have a certain gene in your body that may make you more likely to have an allergic reaction from Abacavir.
Warnings for special population

Pregnancy

Abec-L Tablet may be unsafe for use during pregnancy as animal studies indicate that it may harm the developing foetus. However, there are no human data available. Hence, consult your doctor if you are pregnant.

Breast-feeding

Abec-L Tablet is not recommended for use while breastfeeding. Also, women with HIV infection are not recommended to breastfeed as the Human immunodeficiency virus (HIV) can be passed to the baby through breastmilk.
General warnings

Immune reconstitution syndrome

Changes in your immune system can occur when you start taking Abec-L Tablet. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. It may cause an exaggerated response making the symptoms of infection worse. Inform your doctor if you develop any new symptoms after starting treatment with Abec-L Tablet.

Lactic acidosis

Abec-L Tablet should be used with caution due to the increased risk of lactic acidosis (lactic acid buildup in the bloodstream). Consult your doctor immediately if you experience muscle pain, an unusual fruity-smelling breath, extreme weakness, fatigue, breathing difficulty, feeling dizzy or lightheaded, fast or abnormal heartbeat, etc.

Fat redistribution

Abec-L Tablet should be used with caution as it may cause fat gain or fat loss in the body. It may result in central obesity, buffalo hump (excess fat behind the neck), peripheral wasting (difficulty in moving an arm or leg or making any movement), facial wasting (fat loss in the cheeks and temples), breast enlargement, and cushingoid appearance (extra fat build up on the sides of the face and weight gain). Consult your doctor if you have any concerns.

Heart disease

Abec-L Tablet should be used with caution if you have heart problems as this medicine may increase the risk of a heart attack.

Osteonecrosis

Abec-L Tablet should be used with caution as it may rarely cause osteonecrosis (the death of bone cells due to a lack of blood supply). Consult your doctor if you experience joint aches and pain, joint stiffness, or difficulty in movement

Pancreatitis

Pancreatitis refers to the swelling of the pancreas, a gland that produces chemical substances which help in digestion and regulation of blood sugar. Abec-L Tablet should be used with caution as it may cause pancreatitis. The risk is especially higher if you have a history of pancreatitis.

Kidney disease

Abec-L Tablet should be used with caution if you have kidney problems as this medicine is filtered by the kidney. If you have impaired kidney function, it may cause an accumulation of this medicine in your body and increase the risk of undesired effects. Your doctor may adjust the dose based on your clinical condition.

Use in children

Abec-L Tablet is not recommended for use in children weighing less than 25 kg.

Missed Dose

Take the missed dose of Abec-L Tablet as soon as you remember. Skip the missed dose if it is time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Never take more than the prescribed dose of Abec-L Tablet. Seek emergency medical treatment in case of an overdose of this medicine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Abec-L Tablet due to the increased risk of side effects.
Interaction with Medicine

Epirubicin

Methotrexate

Ribavirin

Efavirenz

Disease interactions

Kidney disease

Abec-L Tablet is filtered in kidneys therefore, should be used with extreme caution if you have mild to moderate kidney disorders. Your doctor can adjust your dose or replace it with another medicine according to your condition.

Cardiovascular disease

Abec-L Tablet should be used with caution if you have a history of heart problems as it may worsen your condition. Your doctor may closely monitor your heart function during treatment with this medicine.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Abec-L Tablet exactly as instructed by your doctor. Do not take in larger or smaller quantities than recommended. Your doctor may suggest tests to periodically monitor your liver function while you are taking this medicine. Taking Abec-L Tablet will not prevent the transmission of HIV to others. Hence, avoid having unprotected sexual intercourse or sharing razors or toothbrushes.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
Abec-L Tablet works by stopping the human immunodeficiency virus (HIV) from multiplying. This helps in delaying the progression of acquired immunodeficiency syndrome (AIDS) and other HIV-related conditions.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Antiviral combinations

Schedule

Schedule H

Dailymed.nlm.nih.gov. 2022. These highlights do not include all the information needed to use Abacavir and Lamivudine tablets safely and effectively. See full prescribing information for Abacavir and Lamivudine tablets. Abacavir and Lamivudine tablets, for oral useInitial U.S. Approval: 2004. [online] Available at: < [Accessed 1 March 2022].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=133490fc-26eb-4c92-a21d-52be4c226b74>

Medicines.org.uk. 2022. Abacavir 300 mg Film-Coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 1 March 2022].

https://www.medicines.org.uk/emc/product/10525>

Accessdata.fda.gov. 2022. [online] Available at: < [Accessed 1 March 2022].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021652s022lbl.pdf>

Hivdb.stanford.edu. 2022. [online] Available at: < [Accessed 1 March 2022].

https://hivdb.stanford.edu/pages/linksPages/ABC_3TC_Combination.pdf>

Medicines.org.uk. 2022. Lamivudine Tablet 300mg - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 1 March 2022].

https://www.medicines.org.uk/emc/product/7065>

Medicines.org.uk. 2022. Abacavir/Lamivudine 600 mg/300 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 2 March 2022].

https://www.medicines.org.uk/emc/product/7375/smpc#gref>
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Information on this page was last updated on 2 Mar 2022

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