5-Fluorouracil (topical)

Description

5-Fluorouracil (topical) is a chemotherapy drug used to treat basal cell cancer of the skin. It is also used for the treatment of a pre-cancerous skin condition known as actinic keratoses. This medicine is not recommended for use in patients less than 18 years of age.

Side effects

Major & minor side effects for 5-Fluorouracil (topical)

  • Application site redness, itching, and burning
  • Photosensitivity of skin
  • Oozing
  • Soreness or tenderness of skin
  • Darkening of skin
  • Scaly skin
  • Watery eyes

Uses of 5-Fluorouracil (topical)

What is it prescribed for?

  • Basal cell carcinoma
  • Actinic Keratoses
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women since the risk of fetal harm is significantly high. Your doctor may prescribe an alternative medicine based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

Pregnancy

This medicine is not recommended for use in pregnancy and in women who may become pregnant due to the increased risk of fetal harm.

Dihydropyrimidine dehydrogenase deficiency

This medicine is not recommended for use in patients with an inherited deficiency of an enzyme called Dihydropyrimidine dehydrogenase since the risks of toxicity and fatal adverse effects are significantly higher in such patients.

Allergy

This medicine is not recommended for use in patients with a known allergy to 5-Fluorouracil, capecitabine, or any other inactive ingredient present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women since the risk of fetal harm is significantly high. Your doctor may prescribe an alternative medicine based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings

Other medicines

5-Fluorouracil (topical) may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Contraception

It is advised to use suitable methods of contraception during and after therapy with this medicine. Pregnancy should be avoided while receiving this medicine. Contact your doctor immediately if pregnancy is suspected.

Photosensitivity

This medicine may make you more sensitive to sunlight or tanning lights. You are advised to use sunscreen and wear protective clothing to avoid adverse reactions to sunlight during treatment with this medicine.

Infections

Use of this medicine may weaken the immune system and make you more susceptible to opportunistic infections. Hence, it is recommended to take suitable precautionary measures to avoid infections during treatment with this medicine. Report any unusual symptoms to the doctor. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not apply a double dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact your doctor immediately if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Apply a thin layer of the cream to the affected area as instructed by the doctor. Follow all the usage instructions mentioned on the label or the package insert. Do not apply in larger or smaller quantities than recommended. Do not cover the application area with bandages or other coverings unless specifically instructed by the doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by slowing or stopping the growth of cancer cells in the body.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Topical antineoplastics

Schedule

Schedule H

[Internet]. Bccancer.bc.ca. 2018 [cited 22 August 2018]. Available from:

http://www.bccancer.bc.ca/drug-database-site/drug%20index/fluorouracil_monograph_1sep2015.pdf

Fluorouracil [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 22 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/5-Fluorouracil#section=Top

Fluorouracil - DrugBank [Internet]. Drugbank.ca. 2018 [cited 22 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB00544

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Information on this page was last updated on 27 Dec 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.