ankle swelling (peripheral edema) in your case may relate to several possible causes:
1.
Uric Acid Elevation (Hyperuricemia)
Gout due to hyperuricemia can cause joint pain and swelling, often in lower extremities.
However, gout attacks usually cause painful, red, hot joints rather than just soft swelling.
2. Medication Side Effects
Olisure F5 contains olanzapine (atypical antipsychotic), known to cause:
Peripheral edema as an uncommon side effect.
Mechanism may involve vasodilation or fluid retention, not necessarily cardiac or renal in origin.
Clonazepam (Lonazep) is less commonly associated with edema, but it may additively contribute via CNS or hypotensive effects.
3. Other common causes to consider:
Renal dysfunction: Already being monitored through KFT.
Cardiac causes: Less likely given normal ECG, ECHO, Holter.
Hepatic causes: Consider if any abnormal
LFT or symptoms like fatigue/jaundice.
Next Steps:
Consider switching or tapering olanzapine under psychiatric supervision if the edema worsens or persists.
Rule out proteinuria, serum
albumin, and repeat KFT to reassess renal contribution.
Reduce dietary salt intake and elevate legs periodically.
Reference: Harrison’s Manual of Medicine, 20th Ed – Edema causes and drug-induced edema.
MARK HELPFUL 🙂🙂🙂