This can happen with mirtazapine. It strongly increases appetite via antihistamine and 5-HT2C blockade, and in some people the increased hunger and sleep disturbance can persist for a few weeks even after stopping, especially if sleep is still not well regulated. However, persistence beyond 3–4 weeks with significant distress (night awakenings due to hunger, difficulty sleeping) is not typical and should be evaluated. It’s also important to rule out other causes like anxiety, rebound insomnia, or less commonly metabolic issues. Please consult a psychiatrist for proper assessment and guidance treatment may be needed to normalize sleep and appetite.
Answered2026-04-26 12:48:36
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