Hello there....., It might take several weeks for the tenderness to disappear. Resting, supporting the scrotum with an athletic strap, applying ice packs and taking pain medication can help relieve discomfort. Your doctor is likely to recommend a follow-up visit to check that the infection has completely cleared up. If it hasn't, your doctor might prescribe another antibiotic. However, for most people epididymitis clears up within three months.