There could be a variety of factors leading up to your husband's current state of mind. I can understand that you must be going through a lot at this stage. It would be prudent to consult a Psychiatrist for detailed assessment with regard to the following factors: 1. Is there any family history of Psychiatric illness? 2. Is there any past history of such episodes? 3. Is he under any form of severe stress? 4. Has he been compliant with his medication? The psychiatrist will also ask you more questions, to get a better picture of the case. Accordingly, your husband's medication may be changed/optimised. He might also be suggested Psychotherapy, which is a form of non pharmacological management of Depression. Good luck.