Hello Friend, Good that you are seeking a help here for Friend. All he carrying is some kind of emotional baggage in his mind and that is causing depression and anxiety. As body and mind are interlinked, such emotions also exhibits problems at physical condition by disturbed sleep, lethargic, lack of appetite, constipation, tiredness,lack of interest and many more.
No worries. These emotional issues are also similar to any physical illness and can be treated through counseling support and few behavioral therapies or lifestyle changes, exercise etc.
Get your friends for a professional counselling support online if he hesitate to meet directly. He will get a different prepective of his problem and a suitable solution.
Next Steps
Consult him to any psychologists directly or reach me online through Practo for further detailed evaluation and suitable recommendations. He will be alright soon.