Suffering from bipolar disorder since 2014. Main problem is that when he takes anti-depressants he goes in manic state and when he takes anti-psychotics he goes back to depression. His condition is not at all stable and the same thing is repeated one after another. Please suggest some mood stabilizing medicine apart from lithium as his creatinine level increased to 1.98 and estimated GFR was 45 when tested 2 months back and docto said that lithium cannot be given to him because it is affecting his kidneys. From last one week he is on prothiaden 75mg twice a day and DESVAL 250mg thrice a day. But from last 2 days he is not able to sleep properly and is continuously speaking while in sleep. Please assist.