PCOS is a heterogeneous endocrine disorder (hormonal imbalance) of multifactorial etiology and affects 5–10% of reproductive women. More prevalent in obese women (20%) than those who are lean. The effects of PCOS are wide ranging and include gynecological, cardiovascular, metabolic, dermatological and psychological.
There are multiple causative factors in the pathophysiology of PCOS including genetic predisposition, environmental factors, obesity (abdominal type), sedentary life style etc.
Hyperinsulinemic insulin resistance plays a prominent role in PCOS. hyperinsulinemia produces a hyperandrogenic state (excessive levels of male sex hormones such as
testosterone).
SYMPTOMS/ PROBLEMS (associated with PCOS):-
20% cases are asymptomatic
Due to Anovulation :
Amenorrhea (no menstruation)
Oligomenorrhea (infrequent menstrual periods)
Prolonged erratic menstrual bleeding
Infertility
Eendometrial cancer
Due to Hyperandrogenism :
Hirsutism (unwanted male pattern hair growth in women)
Acne
Alopecia
Due to Insulin Resistance :
DyslipidaemiaType 2
Diabeties
Obesity
Long term complications :-
Miscarriage (controversy)
Type 2 diabeties
Cardiovascular risk ( Heart diseases)
Cholesterol abnormalities
Obstructive sleep apnoea
Obesity
Acanthosis nigricans (pigmentation)
Endometrial malignancy
Increased bone mass
Depression
Lifestyle modification is the first line treatment especially for the overweight and obese. The initial pharmacological treatment offered is combination oral contraception pills, since these correct both menstrual abnormalities and hyperandrogenismia. If hirsutism is not controlled satisfactory by cosmetic and OCP treatment, physical hair reduction methods and anti-androgen therapy are added. Metformin is suggested if abnormal glucose tolerance or
lipid abnormalities of the metabolic syndrome cannot be normalized by weight loss