One imp thing is one must not continue longterm medication without supervision of expert doctor. Yes isotretinoin has been know to cause epiphysial defects of bones in kids on long term use. In adults it has been implicated in hyperostosis of bones which again can make bones susceptible to fracture, some studies show isotretinoin increases activity of osteoclasts ie can effect bone strength on long term use.
Answered2019-01-25 09:13:08
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