Trimetazidine
Description
Trimetazidine is used in combination with other drugs for the symptomatic treatment of stable angina pectoris, chest pain caused by decreased oxygen supply due to reduced blood flow to the heart. This medicine is used when patients do not respond adequately to other agents or are intolerant to first line anti-anginal agents.
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Side effects
Major & minor side effects for Trimetazidine
- Hypersensitivity
- Headache
- Nausea and vomiting
- Abdominal pain
- Fatigue
Uses of Trimetazidine
What is it prescribed for?
- Angina pectoris
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Concerns
Commonly asked questions
- Onset of actionThe amount of time required for this medicine to show its action is not clinically established.
- Duration of effectThe amount of time for which this medicine remains active in the body is not clinically established.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Allergy
This medicine is not recommended for use in patients with a known allergy to trimetazidine or any other components present along with it.
Parkinson's disease
This medicine is not recommended for use in patients with Parkinson's disease since it may worsen the symptoms of Parkinson's.
Severe renal impairment
Trimetazidine is not recommended for use in patients with severe renal impairment (CrCl less than 30 ml/minute) due to the increased risk of worsening of the patient's condition.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings
Use in pediatrics
Trimetazidine is not recommended for use in children and adolescents.
Drowsiness
This medicine may cause drowsiness. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery during treatment with this medicine.
Hypotension
Trimetazidine may cause hypotension. This risk is especially higher in patients undergoing treatment with high blood pressure medicines. Close monitoring of blood pressure and appropriate dose adjustments may be required based on the clinical condition.
Geriatric use
Caution is advised while using this medicine in elderly patients above the age of 75 years due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Therapeutic use
Use of this medicine as a first line agent for unstable angina or heart attack is not recommended. This medicine is also not indicated for use as a curative treatment for angina.
Missed Dose
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Metoclopramide
Disease interactions
Disease
Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Trimetazidine with food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
Trimetazidine works by increasing energy supply to the heart muscles through increased glucose utilization.
Legal Status
Classification
Category
Antianginal agents, Vasodilators
Schedule
Schedule H
Trimetazidine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 1 September 2017]. Available from:
Vastarel 20mg - Summary of Product Characteristics (SPC) [Internet]. Medicines.ie. 2017 [cited 1 September 2017]. Available from:
Trimetazidine [Internet]. Snomedbrowser.com. 2017 [cited 1 September 2017]. Available from:
[Internet]. 2017 [cited 1 September 2017]. Available from:
[Internet]. 2017 [cited 13 September 2017]. Available from:
TRIVEDON MR Tablets [Internet]. CiplaMed. 2017 [cited 13 September 2017]. Available from:
Information on this page was last updated on 13 Sep 2017
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.