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Rolimus 10 MG Tablet
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Rolimus 10 MG Tablet

Manufactured byCipla Ltd.
ContainsEverolimus
Description
Rolimus 10 MG Tablet is an immunosuppressant medicine that contains Everolimus. It is used to prevent your immune system from rejecting an organ that has been transplanted via surgery (eg. kidney and liver transplants). It may also be used in combination with other medicines to treat certain types of cancers of the breasts, kidneys, pancreas, intestines, lungs, brain, etc. Rolimus 10 MG Tablet can cause side effects like infections, sinusitis, cough, fever, fatigue, swelling of the mouth, infection of the throat, infection of the ear, and diarrhoea. Inform your doctor if any of these symptoms persist for a long time. Seek medical help if you notice any increase in thirst and frequency of urination or if you have difficulty in breathing. Avoid taking Rolimus 10 MG Tablet if you have a cough or fever, or need to receive any vaccination as it decreases the immune system's ability of your body to fight infection. Rolimus 10 MG Tablet is not recommended for use if you are pregnant, planning pregnancy or breastfeeding. Consult your doctor before using this medicine. Rolimus 10 MG Tablet is not recommended if you have severe liver problems. Inform your doctor if you are using any other medicines for underlying health conditions. Rolimus 10 MG Tablet can cause fatigue so it is advisable to not do any activity that requires your concentration like driving vehicles or operating machines. Avoid drinking grapefruit juice while using Rolimus 10 MG Tablet as a chemical in the juice can interfere with the action and reduce its therapeutic benefits.
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Side effectsConcernsUsageRelated products

Substitutes

List of substitutes for Rolimus 10 MG Tablet

Rolimus 10 Tablet
Cipla Ltd.

Side effects

Major & minor side effects for Rolimus 10 MG Tablet

  • Swelling of the face, arms, hands, lower legs, or feet
  • Chest pain
  • Chills and fever
  • Diarrhoea
  • Difficulty in swallowing
  • Difficult or painful urination
  • Rapid weight gain
  • Tingling of hands or feet
  • Bleeding gums
  • Blurred vision
  • Nausea and vomiting
  • Slow heart rate
  • Sweating
  • Unusual tiredness or weakness
  • Dry skin
  • Headache
  • Hair loss
  • Missed or irregular menstrual periods
  • Cough
  • Irregular breathing

Uses of Rolimus 10 MG Tablet

What is it prescribed for?

  • Organ transplant - rejection prophylaxis
  • Advanced breast cancer
  • Advanced kidney cancer
  • Pancreatic cancer
  • Advanced neuroendocrine cancer
  • Brain/Intracranial tumour
  • Tuberous sclerosis complex (TSC)-associated partial-onset seizures
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Rolimus 10 MG Tablet to show its effect is 1-2 hours after taking it.
  • How long do the effects of this medicine last?
    The amount of time for which Rolimus 10 MG Tablet remains active in the body is not known.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Rolimus 10 MG Tablet.
  • Can this medicine be taken during pregnancy?
    Rolimus 10 MG Tablet is not recommended for use in pregnancy unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    Rolimus 10 MG Tablet is not recommended for use in breastfeeding unless absolutely necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

Avoid taking Rolimus 10 MG Tablet if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Warnings for special population

Pregnancy

Rolimus 10 MG Tablet is not recommended for use in pregnancy unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

Rolimus 10 MG Tablet is not recommended for use in breastfeeding unless absolutely necessary. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Vaccination

The administration of live vaccines is not recommended during treatment with Rolimus 10 MG Tablet due to the increased risk of serious side effects. It is advised to avoid contact with individuals who have received live vaccines. You are also recommended to be up to date with all required immunizations before initiating therapy with this medicine.

Blood sugar levels

Rolimus 10 MG Tablet may increase blood sugar levels. Monitoring of fasting blood sugar levels is recommended before starting the treatment with this medicine and periodically thereafter.

Cholesterol levels

Rolimus 10 MG Tablet may increase cholesterol and triglyceride levels. Monitoring of fasting lipid profile is recommended before starting therapy with this medicine and periodically thereafter.

Wound healing and fluid accumulation

Rolimus 10 MG Tablet may delay wound healing and increase the risk of wound-related complications which may require surgical intervention. It also may cause fluid accumulation, including swelling of feet, other types of localized fluid collections which may lead to further complications.

Infections

The immunosuppressant effect of Rolimus 10 MG Tablet may decrease the resistance to infectious agents and may increase the risk of infections. You are advised to report any unusual symptoms such as a sore throat, pain or burning during urination, fever, chills, etc., to the doctor immediately. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Non-infectious pneumonitis

Rolimus 10 MG Tablet may cause non-infectious pneumonitis. Appropriate dose adjustments should be made based on the severity of the symptoms. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Proteinuria

Rolimus 10 MG Tablet may increase the presence of abnormal quantities of protein in the urine (proteinuria) when it is used along with cyclosporine in people who have undergone transplant surgeries. Monitoring of protein levels in urine is recommended when these medicines are used together. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Infertility

Prolonged therapy with Rolimus 10 MG Tablet may cause male as well as female infertility. If you are a person with reproductive potential, discuss this risk with your doctor before beginning treatment with this medicine.

Stomatitis/Mouth Sores

Rolimus 10 MG Tablet may cause mouth sores. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Hematologic abnormalities

Rolimus 10 MG Tablet should be used with caution if you are predisposed to hematologic changes due to the increased risk of severe hematologic abnormalities. These abnormalities may include decreased levels of haemoglobin, platelets, lymphocytes, white blood cells, etc. Periodic monitoring of complete blood counts is recommended during treatment with this medicine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Missed Dose

Take the missed dose of Rolimus 10 MG Tablet as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Never take more than the prescribed dose of Rolimus 10 MG Tablet. Seek emergency medical treatment or contact your doctor immediately if you suspect that you might have taken an overdose of this medicine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Aliskiren

Angiotensin converting enzyme inhibitors (ACEI's)

Darunavir

Adalimumab

Ketoconazole

Disease interactions

Liver disease

Rolimus 10 MG Tablet should be used with caution if you have liver problems due to the increased risk of severe side effects. Your doctor may suggest tests for monitoring your liver condition while on treatment with this medicine. Also, your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Kidney diseases

Rolimus 10 MG Tablet should be used with caution if you have kidney diseases due to the increased risk of worsening your condition. Your doctor may suggest tests for monitoring your kidney condition while on treatment with this medicine. Also, your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.
Food interactions
Consumption of grapefruit or grapefruit juice is not recommended during treatment with Rolimus 10 MG Tablet due to the increased risk of serious adverse effects.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Rolimus 10 MG Tablet exactly as advised by your doctor. Follow all the usage instructions mentioned on the label/package insert. Do not take in larger amounts than advised. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor. While you are taking Rolimus 10 MG Tablet do not take any vaccinations without consulting your doctor first. Keep Rolimus 10 MG Tablet away from the reach of children and pets. Ensure that the unused medicine is disposed of properly.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Rolimus 10 MG Tablet works by suppressing the immune system which prevents organ rejection after organ transplantation. It also stops cancer cells from multiplying and decrease the blood supply to the cancer cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Selective immunosuppressants , Mtor inhibitors

Schedule

Schedule H

Ema.europa.eu. 2021. [online] Available at: < [Accessed 18 August 2021].

https://www.ema.europa.eu/en/documents/product-information/afinitor-epar-product-information_en.pdf>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 18 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021560s000lbl.pdf>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 18 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022334s6lbl.pdf>

Drugs, H., 2021. Everolimus: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 18 August 2021].

https://medlineplus.gov/druginfo/meds/a609032.html>

Dailymed.nlm.nih.gov. 2021. DailyMed - AFINITOR- everolimus tabletAFINITOR DISPERZ- everolimus tablet, for suspension. [online] Available at: < [Accessed 18 August 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2150f73a-179b-4afc-b8ce-67c85cc72f04>
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Information on this page was last updated on 16 Nov 2021

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