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Xone-XP 125 Injection
Manufactured byALKEM LABORATORIES LTD
ContainsCeftriaxone (125 mg) + Tazobactam (15.625 mg)
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Description
Xone-XP 125 Injection is a combination medicine used to treat a variety of bacterial infections such as community-acquired pneumonia, lower respiratory tract infections, urinary tract infections, skin and skin structure infections, etc. caused by susceptible bacteria.
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Substitutes
List of substitutes for Xone-XP 125 Injection
Side effects
Major & minor side effects for Xone-XP 125 Injection
Nausea
Vomiting
Black or tarry stools
Chest pain
Fever
Difficulty or painful urination
Sore throat
Diarrhea
Abdominal pain
Dizziness
Swelling of face, lips, eyelids, tongue, hands and feet
Acid or sour stomach
Change in taste
Excessive air or gas in stomach
Uses of Xone-XP 125 Injection
What is it prescribed for?
Bacterial infections
This medicine is used for the treatment of infections such as urinary tract infections, intra-abdominal infections, bone and joint infections, skin and skin structure infections, etc. caused by susceptible bacterial species.
Lower Respiratory Tract Infection
This medicine is used in the treatment of infections of the lower respiratory tract caused by bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Pseudomonas species, Klebsiella species, etc.
Community-Acquired Pneumonia
This medicine is used in the treatment of community-acquired pneumonia which is a common type of lung infection caused by bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, etc.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The effect of this medicine occurs rapidly after an intravenous or an intramuscular administration.How long do the effects of this medicine last?
The effect of this medicine lasts for an average duration of 24 hours.Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.Is this a habit forming medicine?
No habit-forming tendencies were reported.Can this medicine be taken during pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.Can this medicine be taken while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
Allergy
This medicine is not recommended for use in patients with a known allergy to ceftriaxone, tazobactam, other beta-lactam antibiotics, or any other inactive ingredients present along with these medicines.
Lidocaine
This medicine is contraindicated for use if Lidocaine is used as a solvent for intravenous injection. Lidocaine can be used as a solvent for the intramuscular injection, despite contraindications, in certain specific conditions.
Calcium-containing products
This medicine is contraindicated for use in neonates who are receiving calcium-containing intravenous solutions or infusions such as parenteral nutrition due to the increased risk of precipitation of this medicine and calcium.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings
Hemolytic anemia
An immune mediated hemolytic anemia has been reported in patients receiving this medicine. Report any unusual symptoms to the doctor immediately. Your doctor may advise you to discontinue the medicine if you develop hemolytic anemia until the exact cause is determined.
Prothrombin time
Alterations in prothrombin time (a test used to check for bleeding problems) have been reported in patients receiving this medicine. Regular monitoring of prothrombin time may be required while receiving this medicine. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition.
Drug-resistance
Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.
Patients with impaired kidney and liver function
This medicine should be used with caution in patients with kidney and liver diseases due to the increased risk of severe adverse effects. Regular monitoring of kidney and liver function tests may be necessary while receiving this medicine. The dose of this medicine should not exceed 2 g/day (ceftriaxone) for such patients.
Clostridium difficile-associated Diarrhea
Antibiotic therapy will cause an imbalance in the normal microbial flora of the large intestine, which may promote the growth of bacteria called Clostridium difficile and patients may experience severe diarrhea as a result. Report any such incidence to the doctor on priority and avoid usage of this medicine in such cases.
Administration
When used intravenously, this medicine should be infused over a duration of at least 30 to 60 minutes. When used intramuscularly, the medicine should be injected over a duration of 2 to 4 minutes.
Missed Dose
Since this medicine is administered in the hospital/clinical setting by a qualified health-care professional, the likelihood of a missed dose is very low. If you miss a scheduled appointment for a dose of this medicine, contact your doctor for further instructions.
Overdose
Since this medicine is administered in the hospital/clinical setting by a qualified health-care professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Amikacin
Cholera Vaccine
Cyclosporine
Probenecid
Entecavir
Disease interactions
Gastrointestinal Diseases
This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Seizure disorders
This medicine should be used with caution in patients with a history of seizure disorders or a family history of seizures since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Direct Coombs test
Report the use of this medicine to the doctor if you are undergoing the Coombs test. A false positive result may be obtained if this test is performed while receiving this medicine. Do not stop the use of any medicine without consulting your doctor.
Urine Glucose
Report the use of this medicine to the doctor if you are undergoing a urine glucose/sugar test. A false positive result may be obtained if this test is performed while receiving this medicine. An alternative test may be considered to evaluate glucose levels. Do not stop the use of any medicine without consulting your doctor.
This medicine should be administered by a qualified health-care professional in the hospital/clinical setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines, including any herbs and supplements, as well as your medical conditions before receiving this medicine.
Miscelleneous
How it works
Ceftriaxone works by interfering with certain processes that help the bacteria to grow and increase in number. Tazobactam inhibits some chemicals produced by the bacteria and makes the bacteria more sensitive to ceftriaxone activity. Thus, their combination is better effective for the treatment of a wide range of bacterial infections.
Legal Status
Classification
Category
Third generation cephalosporins, Beta-lactamase inhibitors
Schedule
Schedule H
Zuventus Healthcare [Internet]. Zuventus.co.in. 2018 [cited 8 August 2018]. Available from:
DailyMed - Ceftriaxone sodium injection, powder, for solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 8 October 2018]. Available from:
Tazobactam - DrugBank [Internet]. Drugbank.ca. 2018 [cited 19 March 2018]. Available from:
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Information on this page was last updated on 8 Oct 2018
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.