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Vinorelbine

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Description

Vinorelbine is an anticancer medicine that is used either alone or in a combination with other medicines for the treatment of non-small cell lung cancer. It is also used to treat breast cancer in patients who have not responded to first-line chemotherapy. This medicine is not recommended for use in patients less than 18 years of age.
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Side effectsConcernsUsage

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Side effects

Major & minor side effects for Vinorelbine

Cough

Fever or chills

Lower back pain

Sore throat

Swelling and redness at the injection site

Chest pain

Shortness of breath

Painful urination

Stomach pain

Skin Rash

Vomiting

Uses of Vinorelbine

What is it prescribed for?

Non-Small Cell Lung Cancer

This medicine is used in the treatment of non-small cell lung cancer. It is a type of lung cancer characterized by symptoms such as a persistent cough, shortness of breath, weight loss, coughing up blood, etc.

Breast cancer

This medicine is used for the treatment of breast cancer in patients who have not responded to first-line chemotherapy.
Concerns

Commonly asked questions

  • Onset of action

    The amount of time required by this medicine to show its action is not clinically established.

  • Duration of effect

    The amount of time for which this medicine remains active in the body is not clinically established.

  • Safe with alcohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit-forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to vinorelbine or any other inactive ingredients present along with it.

Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

General warnings

Hepatic Impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Neuropathy

This medicine should be used with caution in patients suffering from neuropathy due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart diseases

This medicine should be used with extreme caution in patients suffering from heart diseases due to the increased risk of severe adverse effects. Close monitoring of heart function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bone marrow depression

This medicine should be used with extreme caution in patients with bone marrow depression or low blood counts due to the increased risk of worsening of the patient's condition. Report any unusual signs and symptoms such as fever, sore throat, bleeding, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Vaccination

Report the use of either the medicine or the vaccine to the doctor. Your doctor may advise you to postpone administration of either the vaccine or the medicine, based on your clinical condition, to avoid their interaction.

Severe constipation and bowel obstruction

This medicine may cause severe constipation, bowel obstruction or perforation in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Infection

This medicine should be used with caution in patients with severe infection or patients who have had a recent infection due to the increased risk of severe adverse effects. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Injection: Since this medicine is administered by a qualified health care professional in the clinical or hospital setting, the likelihood of a missed dose is very low. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions. Capsule: If you miss a dose of this medicine, contact your doctor immediately for further instructions.

Overdose

Injection: Since this medicine is administered in the hospital setting by a qualified health care professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected. Capsule: Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Atazanavir

Infliximab

Nefazodone

Adalimumab

Voriconazole

Erythromycin

Clozapine

Ritonavir

Disease interactions

Disease

Information not available.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Injection: This medicine should be administered by a qualified healthcare professional in the clinical or hospital setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Capsule: Take this medicine exactly as advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.

Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Effect on sleep is not established

How it works

This medicine works by stopping or slowing the growth and spread of cancer cells in the body.

Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Mitotic inhibitors

Schedule

Schedule H

Vinorelbine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 12 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00361

[Internet]. Medicines.org.uk. 2018 [cited 12 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.3912.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 12 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/20388S014lbl.pdf

Vinorelbine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 12 September 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a695013.html

[Internet]. Hpra.ie. 2018 [cited 12 September 2018]. Available from:

https://www.hpra.ie/img/uploaded/swedocuments/2187849.PA1287_001_005.159544c5-fd98-4a9e-aa0b-8757a2ba7806.000001Product%20Leaflet%20Approved.170206.pdf

[Internet]. Hpra.ie. 2018 [cited 12 September 2018]. Available from:

https://www.hpra.ie/img/uploaded/swedocuments/2187851.PA1287_001_001.044854be-1922-4438-9714-543cd256aa63.000001Product%20Leaflet%20Approved.170206.pdf
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Information on this page was last updated on 18 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.