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Triumeq Tablet
Manufactured byGLAXOSMITHKLINE PHARMACEUTICALS LTD
ContainsAbacavir (600 mg) + Dolutegravir (50 mg) + Lamivudine (300 mg)
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Description
Triumeq Tablet is a combination medicine used for the treatment of human immunodeficiency virus (HIV) infections in adult and adolescent patients weighing more than 40 kg. This medicine is not a cure for HIV; it only prevents the virus from multiplying in your body. Monitoring of liver function and kidney function may be necessary while receiving this medicine based on the clinical condition.
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Substitutes
List of substitutes for Triumeq Tablet
Side effects
Major & minor side effects for Triumeq Tablet
Sleeplessness
Nausea and Vomiting
Stomach pain
Dark urine
Loss of appetite
Weight loss or weight gain
Yellow eyes or skin
Headache
Depression
Muscle pain
Sore throat
Diarrhea
Skin Rash
Unusual tiredness
Itching of skin
Difficulty in breathing
Uses of Triumeq Tablet
What is it prescribed for?
HIV infection
This medicine is used in the treatment of human immunodeficiency virus (HIV) infection.
Concerns
Commonly asked questions
How long does it take for this medicine to take effect?
The amount of time required for this medicine to show its action is not clinically established.How long do the effects of this medicine last?
The amount of time for which this medicine remains active in the body is not clinically established.Is it safe to consume alcohol while taking this medicine?
Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.Is this a habit forming medicine?
No habit-forming tendencies were reported.Can this medicine be taken during pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.Can this medicine be taken while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
Allergy
This medicine is not recommended for use if you have a known allergy to abacavir, dolutegravir, lamivudine, or any other inactive ingredients present in the formulation.
Dofetilide
This medicine is not recommended for use in patients receiving dofetilide as it may increase the undesired effects of dofetilide which may lead to potentially serious and life-threatening side effects.
HLA-B*5701-positive patients
This medicine is not recommended for use in patients who have screened positive for human leukocyte antigen HLA-B*5701 due to the increased risk of severe hypersensitivity reactions.
Moderate to Severe Hepatic Impairment
This medicine is not recommended for use in patients with moderate to severe liver impairment since it may worsen the patient's condition.
Kidney impairment
This medicine is not recommended for use in patients with a creatinine clearance of less than 50 ml/min.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
General warnings
Hepatotoxicity
This medicine should be used with caution in patients with pre-existing liver disease, history of alcohol abuse, or hepatitis due to increased risk of worsening of patient's condition. Close monitoring of liver function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Immune reconstitution syndrome
This medicine should be used with caution due to the increased risk of Immune reconstitution syndrome. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Hypersensitivity reactions
This medicine may cause severe allergic reactions such as skin rash, organ dysfunction, liver injury, etc. in some patients on therapy. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Lactic acidosis
This medicine should be used with caution due to the increased risk of Lactic acidosis. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Pancreatitis
This medicine may cause pancreatitis in some patients. Report any unusual symptoms to the doctor immediately. Therapy may need to be discontinued if the patient develops any signs or symptoms of pancreatitis.
Fat Redistribution
This medicine may cause fat gain or fat loss from the body. This may result in peripheral wasting, facial wasting, breast enlargement, and Cushingoid appearance. Close monitoring of body weight and body fat distribution is necessary while receiving this medicine. Any changes in the body should be informed to the doctor on priority.
Diabetes
This medicine may alter blood glucose levels and may also increase the risk of new-onset diabetes mellitus. Close monitoring of blood glucose levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Use in children
This medicine is not recommended for use in pediatric patients weighing less than 40 kg since the safety and efficacy of use are not clinically established.
Driving or operating machinery
This medicine may cause dizziness or fatigue in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Opportunistic infections
The patients receiving this medicine may develop opportunistic infections such as pneumonia, herpes virus infections, etc. Report any unusual symptoms to the doctor immediately. Appropriate patient/caregiver education, corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Missed Dose
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.
Interaction with Medicine
Epirubicin
Methotrexate
Aluminium Hydroxide
Ribavirin
Efavirenz
Phenytoin
Metformin
Dofetilide
Phenobarbital
Disease interactions
Liver impairment
This medicine should be used with extreme caution in patients suffering from mild liver impairment due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with moderate to severe liver impairment.
Pancreatitis
This medicine may cause pancreatitis in some patients on therapy. Report any symptoms of pancreatitis such as nausea, vomiting, stomach pain, etc. to the doctor immediately. Therapy may need to be discontinued if the patient develops any signs or symptoms of pancreatitis. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.
Cardiovascular disease
This medicine should be used with caution in patients with a history of heart diseases and active heart disease due to the increased risk of worsening of the patient's condition. Close monitoring of heart function is advised during treatment with this medicine. Dose adjustments may be required based on the clinical condition.
Food interactions
Coadministration of multivitamins and Triumeq Tablet may decrease the effectiveness of the combination medicine. To avoid the interaction your doctor may suggest maintaining a time gap of at least 2 or 6 hours between the administration of this medicine and multivitamins.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller quantities than recommended. Ensure that proper hygiene measures are adopted. Complete the course of treatment to prevent the spread of the infection. Close monitoring of liver function and kidney function may be necessary while receiving this medicine based on the clinical condition.
Miscelleneous
How it works
This medicine works by stopping the human immunodeficiency virus (HIV) from multiplying. This helps in reducing the chances of development of acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses.
Legal Status
Classification
Category
Antiviral combinations
Schedule
Schedule H
DailyMed - Triumeq - abacavir sulfate, dolutegravir sodium, lamivudine tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 19 September 2019]. Available from:
Triumeq Dosage, Side Effects [Internet]. AIDSinfo. 2019 [cited 19 September 2019]. Available from:
Triumeq 50 mg/600 mg/300 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2019 [cited 19 September 2019]. Available from:
[Internet]. Ema.europa.eu. 2019 [cited 19 September 2019]. Available from:
Related Questions
Information on this page was last updated on 20 Sep 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.