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Sodium Nitroprusside

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Description

Sodium Nitroprusside is used to lower the blood pressure and to treat heart failure. It also helps in producing controlled low blood pressure during surgeries to reduce the bleeding.
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Side effectsConcernsUsage

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Side effects

Major & minor side effects for Sodium Nitroprusside

Chest pain or discomfort

Injection site pain

Fast or irregular heartbeat

Trouble breathing

Dizziness

Headache

Constipation

Weight gain

Uses of Sodium Nitroprusside

What is it prescribed for?

Hypertensive Emergency

This medicine is used to lower the blood pressure during a hypertensive crisis (a life-threatening high blood pressure). It also helps in producing controlled low blood pressure during surgeries to reduce the bleeding.

Congestive Heart Failure

This medicine is used in the treatment of congestive heart failure, a condition where the heart doesn't pump blood adequately.
Concerns

Commonly asked questions

  • Onset of action

    The effect of this medicine can be observed within 2 minutes of administration of the dose.

  • Duration of effect

    The effect of this medicine lasts for an average duration of 1 to 10 minutes.

  • Safe with alcohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit-forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for pregnant women unless absolutely necessary. The potential benefits and risks should be discussed with the doctor before receiving this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended in breastfeeding women unless absolutely necessary. The potential benefits and risks should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to sodium nitroprusside or any other inactive ingredients present along with it.

Compensatory Hypertension

This medicine is not recommended for use in patients with compensatory hypertension due to the risk of worsening of the patient's condition.

Acute congestive heart failure due to reduced peripheral vascular resistance

This medicine is not recommended for use in patients with acute congestive heart failure associated with decreased peripheral vascular resistance due to the risk of worsening of the patient's condition.

Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women unless absolutely necessary. The potential benefits and risks should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended in breastfeeding women unless absolutely necessary. The potential benefits and risks should be discussed with the doctor before receiving this medicine.

General warnings

Intracranial hypertension

This medicine should be used with caution in patients with intracranial hypertension (increased pressure within the brain) due to the increased risk of adverse effects. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver impairment

This medicine should be used with caution in patients with liver impairment due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Kidney impairment

This medicine should be used with caution in patients with kidney impairment due to the increased risk of adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hypothyroidism

This medicine should be used with caution in patients with hypothyroidism (a condition of lack of enough thyroid hormones) due to the increased risk of adverse effects. Close monitoring of thyroid function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Cyanide toxicity

Cyanide toxicity may occur in some patients on therapy with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Corticosteroids

Alprazolam

Tizanidine

Asenapine

Disease interactions

Cerebral vascular insufficiency

This medicine is not recommended for use in patients with conditions that obstruct the arteries that supply blood to the brain due to the risk of worsening of the patient's condition. An alternative treatment option should be considered based on the clinical condition of the patient.

Anemia

This medicine should be used with extreme caution in patients with anemia due to the risk of worsening of the patient's condition. The anemia should be corrected in such patients before starting therapy with this medicine. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Liver impairment

This medicine should be used with caution in patients with liver impairment due to the increased risk of adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.

Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works

This medicine relaxes and dilates the blood vessels. This allows the blood to circulate freely and smoothly and reduces blood pressure.

Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Vasodilators, Agents for hypertensive emergencies

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2019 [cited 1 April 2019]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/207426Orig1s000lbl.pdf

DailyMed - Sodium Nitroprusside - sodium nitroprusside injection [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 1 April 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5a599880-c133-44ef-a9f2-bd1b681563be

Nitroprusside - DrugBank [Internet]. Drugbank.ca. 2019 [cited 1 April 2019]. Available from:

https://www.drugbank.ca/drugs/DB00325
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Information on this page was last updated on 1 Apr 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.