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Pipzo 4.5 Injection

Manufactured byALKEM LABORATORIES LTD
ContainsPiperacillin (4000 mg) + Tazobactam (500 mg)
CURRENTLY UNAVAILABLE

Description

Pipzo 4.5 Injection is a combination of Piperacillin and Tazobactam. It is used for the treatment of bacterial infections that affect the lungs, urinary tract, skin, etc. This medication is effective only for the treatment of infections caused by bacteria and not viruses. Pipzo 4.5 Injection is effective against a large number of bacteria. Piperacillin works by preventing the formation of bacterial cell walls and killing the infection-causing bacteria. Tazobactam protects Piperacillin and ensures extended anti-bacterial activity. Pipzo 4.5 Injection may cause some common side effects such as diarrhoea, upset stomach, headache, sleeplessness, skin rash and itching, etc. Consult your doctor if these symptoms persist or if they become severe. Pipzo 4.5 Injection is given by your doctor in a clinic or a hospital setting. The dose and duration of the treatment will depend on your condition. Follow the instructions given by your doctor and continue receiving the medicine for the prescribed duration. Not completing the full course of therapy may result in decreased effectiveness of the medicine or an increased risk of re-infection that would be difficult to treat in the future. Pipzo 4.5 Injection is not recommended if you are allergic to it. This medicine is not advisable for children below 2 years of age. Inform your doctor if you have any kidney/liver problems or a history of seizures (fits) before starting treatment with this medicine. Consult your doctor if you are pregnant or are breastfeeding.
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Substitutes

List of substitutes for Pipzo 4.5 Injection

Side effects

Major & minor side effects for Pipzo 4.5 Injection

Diarrhoea

Headache

Sleeplessness

Abdominal pain

Nausea and Vomiting

Stomach upset

Skin rash and itching

Fever

Injection site reactions (redness, pain, swelling)

Joint and muscle pain

Uses of Pipzo 4.5 Injection

What is it prescribed for?

Community acquired pneumonia

Community-acquired pneumonia (CAP) refers to pneumonia (lung infection) that is acquired outside the hospital. CAP can be bacterial or viral. Pipzo 4.5 Injection is used to treat CAP caused by bacteria Haemophilus influenzae.

Nosocomial Pneumonia or Hospital-acquired Pneumonia (HAP)

Nosocomial Pneumonia refers to pneumonia (lung infection) that is acquired in the hospital. Pipzo 4.5 Injection is used to treat HAP caused by the bacteria Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumoniae, etc.

Urinary Tract Infection

Urinary Tract Infection is an infection in any part of your urinary system. It may affect your kidneys, bladder, or urethra. Symptoms may include increased urge to urinate, pain during urination, blood in the urine, back pain, nausea, vomiting, fever, etc. Pipzo 4.5 Injection is used in the treatment of urinary tract infection.

Intra abdominal infection

Intra-abdominal infection is a broad term that includes a number of infections of the organs of the abdomen. It includes peritonitis (swelling of the lining of the abdominal wall), diverticulitis (swelling of diverticula- one or more small pouches in the intestine), cholecystitis (swelling of the gallbladder), cholangitis (swelling of the bile duct system), and pancreatitis (swelling of the pancreas). Pipzo 4.5 Injection is used in the treatment of these infections.

Skin and Skin Structure Infection

Pipzo 4.5 Injection is used in the treatment of skin and skin structure infections such as cellulitis (serious bacterial skin infection, usually affecting lower legs), cutaneous abscesses (skin infection with the presence of pus), and diabetic foot infections (foot infection due to diabetes) caused by bacteria Staphylococcus aureus.

Bacterial Septicaemia

Septicaemia, also known as blood poisoning is a serious infection of the blood. It occurs when a bacterial infection in any part of the body (such as the lungs or the skin) enters the bloodstream. Pipzo 4.5 Injection is used in the treatment of bacterial septicaemia.

Neutropenia

Neutropenia is a condition with decreased number of neutrophils, a type of white blood cell that helps fight infections in your body. Neutropenia increases your risk of developing infections. Pipzo 4.5 Injection is used in the treatment of fever associated with neutropenia.
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?

    The time required for Pipzo 4.5 Injection to show its action is not clinically known.

  • How long do the effects of this medicine last?

    The effect of Pipzo 4.5 Injection lasts for an approximate duration of 4-7 hours after taking it.

  • Is it safe to consume alcohol while taking this medicine?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is this a habit forming medicine?

    No habit-forming tendencies have been reported with Pipzo 4.5 Injection.

  • Can this medicine be taken during pregnancy?

    Due to a lack of safety and efficacy studies in pregnant women, the risk to your developing foetus is not known. If you are pregnant, take Pipzo 4.5 Injection only if prescribed by your doctor.

  • Can this medicine be taken while breast-feeding?

    Pipzo 4.5 Injection passes into breast milk in very low quantities and may cause diarrhoea in your breastfed infant. If you are breastfeeding, consult your doctor.

Allergy

Avoid taking Pipzo 4.5 Injection if you are allergic to it. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.

Warnings for special population

Pregnancy

Due to a lack of safety and efficacy studies in pregnant women, the risk to your developing foetus is not known. If you are pregnant, take Pipzo 4.5 Injection only if prescribed by your doctor.

Breast-feeding

Pipzo 4.5 Injection passes into breast milk in very low quantities and may cause diarrhoea in your breastfed infant. If you are breastfeeding, consult your doctor.

General warnings

Antibiotic resistance

Antibiotic resistance is a condition in which the antibiotic is not effective against the bacteria. This can be avoided by completing the entire course of treatment with Pipzo 4.5 Injection as prescribed by your doctor.

Diarrhoea

Pipzo 4.5 Injection can cause diarrhoea because it may also kill the helpful bacteria in your stomach or intestine. Get emergency medical help if you experience severe watery or bloody diarrhoea. Consult your pharmacist/doctor before taking anti-diarrhoeal medication.

Skin reactions

Pipzo 4.5 Injection may cause allergic skin reactions. Inform your doctor if you experience any signs and symptoms of skin reaction such as skin rash, severe itching/swelling on your face/body.

Intravenous administration

Pipzo 4.5 Injection is given as a slow intravenous infusion in a clinic/hospital setting.

Use in children

Pipzo 4.5 Injection is not recommended for use in children below 2 years of age due to a lack of safety and efficacy data.

Seizures

Pipzo 4.5 Injection should be given with caution if you have any pre-existing kidney problems or a history of seizures (fits) due to the increased risk of a seizure attack.

Bleeding problems

Pipzo 4.5 Injection may increase your risk of bleeding. This risk is especially higher if you have any pre-existing kidney problems. Your doctor may recommend tests (prothrombin time) to monitor your bleeding problems.

Low white blood cell count

Pipzo 4.5 Injection may increase your risk of leukopenia and neutropenia (decreased number of leukocytes and neutrophils, a type of white blood cells), especially with prolonged therapy. Your blood cell count will be closely monitored.

Driving or operating machinery

Pipzo 4.5 Injection may cause sleeplessness. Do not drive or operate machines if you experience any symptoms that may affect your mental alertness.

Missed Dose

Since Pipzo 4.5 Injection is given by a qualified healthcare professional in the clinic/hospital setting, the likelihood of a missed dose is very low.

Overdose

Since Pipzo 4.5 Injection is given in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Live vaccines

Methotrexate

Doxycycline

Ethinyl Estradiol

Warfarin

Disease interactions

Kidney Disease

Pipzo 4.5 Injection is eliminated by kidneys and should be used with caution if you have pre-existing kidney problems due to the increased risk of side effects, resulting from the accumulation of this medicine in your body. Your kidney function will be closely monitored and the dose may be adjusted based on your clinical condition.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Pipzo 4.5 Injection is given by a qualified healthcare professional in a clinic/hospital setting. Follow all the instructions given by your doctor. If you experience any redness/pain/swelling at the site of injection that becomes bothersome, inform your doctor immediately. Pipzo 4.5 Injection may lower your white blood cell count. Periodic monitoring of your blood cell count is recommended. Pipzo 4.5 Injection may increase your risk of seizures (fits). Inform your doctor if you have any history of seizures before starting treatment with this medicine.

Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works

Pipzo 4.5 Injection is a combination of Piperacillin and Tazobactam. Piperacillin works by preventing the formation of bacterial cell walls, the outer covering required for cells to stay alive and thereby effectively killing the bacteria. Tazobactam works by preventing bacteria from destroying Piperacillin. Thus, this combination is effective against an extended range of bacteria.

Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Penicillin Beta-Lactam Antibiotics, Beta-lactamase inhibitors

Schedule

Schedule H

Drugs, H., 2021. Piperacillin and Tazobactam Injection: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 22 September 2021].

https://medlineplus.gov/druginfo/meds/a694003.html>

Medicines.org.uk. 2021. Tazocin 4 g / 0.5 g powder for solution for infusion - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 22 September 2021].

https://www.medicines.org.uk/emc/product/1267/smpc>

Medicines.org.uk. 2021. [online] Available at: < [Accessed 22 September 2021].

https://www.medicines.org.uk/emc/files/pil.1267.pdf>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 22 September 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/050684s88s89s90_050750s37s38s39lbl.pdf>

Dailymed.nlm.nih.gov. 2021. DailyMed - PIPERACILLIN AND TAZOBACTAM injection, powder, lyophilized, for solution. [online] Available at: < [Accessed 22 September 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9b682c66-61c6-4ade-baf4-9d68911a16b8>

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Information on this page was last updated on 25 Oct 2021

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.