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OnabotulinumtoxinA

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Description

OnabotulinumtoxinA is a chemical substance produced from a bacteria called Clostridium botulinum which is used for the treatment of spasticity of the upper and lower limb, cervical dystonia (severe spasms in the neck muscles), certain eye muscle conditions that occur due to nerve disorders, chronic migraine, bladder disorders, excessive sweating, etc. It is also used for certain cosmetic uses such as improvement in the appearance of moderate to severe glabellar lines and to lessen the appearance of facial wrinkles.
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Side effects

Major & minor side effects for OnabotulinumtoxinA

Difficulty in breathing

Change in walking and balance

Drowsiness

Headache

Skin rash

Pain at injection site

Muscle weakness

Blurred vision

Bloody or cloudy urine

Facial pain

Swelling of the eyelids

Uses of OnabotulinumtoxinA

What is it prescribed for?

Muscle spasticity

This medicine is used for the treatment of muscle spasticity (a condition of muscle stiffness and tightness) of upper and lower limbs (arms and legs) in adult patients. It is also used for the treatment of muscle spasticity of upper limbs (arms) in pediatric patients.

Blepharospasm

This medicine is used for the treatment of abnormal contraction of the eyelid muscles or eye twitching that occur due to nerve disorders.

Cervical Dystonia

This medicine is used for the treatment of cervical dystonia, also known as spasmodic torticollis, which is a painful condition where the neck muscles contract involuntarily, causing your head to twist or turn to one side.

Overactive Bladder

This medicine is used for the treatment of overactive bladder with urinary incontinence, urgency, and frequency in patients who have shown an inadequate response to or cannot use anticholinergic medications.

Facial lines

This medicine is used for the treatment of moderate to severe vertical lines between the eyebrows (glabellar lines), moderate to severe lateral canthal lines (crow's feet lines), and moderate to severe forehead lines seen at maximum eyebrow elevation.

Chronic migraine

This medicine is used for the prevention of severe throbbing headaches in adult patients.

Strabismus

This medicine is used for the treatment of strabismus or crossed eye, an eye condition where the eyes do not properly align with each other and point in different directions.

Hyperhidrosis

This medicine is used for the treatment of excessive sweating in patients who have shown an inadequate response to topical agents.
Concerns

Commonly asked questions

  • Onset of action

    The amount of time taken by this medicine to show its effect is subject to vary based on the individuals and intended use.

  • Duration of effect

    The amount of time for which this medicine remains effective is subject to vary based on the individuals and intended use.

  • Safe with alcohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit-forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to OnabotulinumtoxinA or any other inactive ingredients present along with it.

Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after assessing the condition and evaluating the risks and benefits associated with the use of this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

General warnings

Severe allergic reactions

Severe allergic reactions or hypersensitivity reactions, including anaphylactic shock, low blood pressure, breathing difficulties, urticaria (skin rash), etc. may occur with this medicine. If symptoms of allergic reactions occur, discontinue immediately and initiate appropriate treatment.

Driving or operating machinery

This medicine may cause loss of strength, drowsiness, dizziness, and visual disturbances in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery immediately after treatment with this medicine.

Infections

This medicine should not be used in patients with an infection at the proposed therapy site since it may worsen the patient's existing condition.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Nortriptyline

Streptomycin

Atracurium

Amoxapine

Gentamicin

Imipramine

Disease interactions

Respiratory Diseases

This medicine should be used with extreme caution in patients with respiratory diseases due to the risk of breathing difficulties. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Dysphagia

This medicine should be used with extreme caution in patients with pre-existing swallowing disorders due to the risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Urinary tract infection

This medicine should not be used for the treatment of overactive bladder in patients with urinary tract infection due to the risk of worsening of the patient's condition. Replacement with a suitable alternative may be required in some cases based on the clinical condition.

Food interactions

Information not available.

Lab interactions

Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine. Close monitoring of the patient for the development of any excessive muscle weakness, severe dysphagia, and respiratory compromise is recommended. The botulinum toxin should only be used if the benefit of treatment is considered to outweigh the risk.

Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works

This medicine works by inhibiting the release of a chemical called acetylcholine that causes muscle contraction.

Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Skeletal muscle relaxants, Neuromuscular blocking agents

Schedule

Schedule H

[Internet]. Allergan.com. 2019 [cited 10 September 2019]. Available from:

https://www.allergan.com/assets/pdf/botox_pi.pdf

[Internet]. Medicines.org.uk. 2019 [cited 3 January 2019]. Available from:

https://www.medicines.org.uk/emc/product/859/smpc

[Internet]. Ebs.tga.gov.au. 2019 [cited 3 January 2019]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-07059-3

OnabotulinumtoxinA Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 10 September 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a608013.html
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Information on this page was last updated on 10 Sep 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.